Department of Dermatology, University of California, Irvine, Irvine, California.
School of Medicine, University of California, Irvine, Irvine, California.
Dermatol Surg. 2021 Jan 1;47(1):70-74. doi: 10.1097/DSS.0000000000002484.
Periorbital hyperpigmentation (POH) is an aesthetic concern for patients. Etiologies of the condition include pigmentary, structural, vascular, and mixed causes.
To systematically review the current literature for treatment of POH.
A systematic literature review was performed on PubMed. Search terms included "infraorbital dark circles," "dark circles," "periorbital hyperpigmentation," "idiopathic hyperchromia AND orbital," "under-eye circles," "ICHOR (idiopathic cutaneous hyperchromia of the orbital region)," "dark circles" AND "treatment," and "filler" AND "dark circles."
A total of 39 studies were included. Effective treatments for POH include lasers, topical creams and serums, fillers, chemical peels, carboxytherapy, plasma-rich platelet injections, blepharoplasty, and normobaric oxygen.
Soft tissue fillers and autologous fat grafting are most effective in treating dark circles due to volume loss. Blepharoplasty surgery is best when excessive skin laxity is the underlying cause. Various topical creams and chemical peels are useful in treating pigment-based POH, whereas lasers are mildly to moderately beneficial for both vascular and pigment types. Given the scarcity of high-quality evidence supporting these results, recommendations should be interpreted selectively. Additional randomized clinical trials studying POH will be helpful.
眶周皮肤色素沉着（POH）是患者关注的美学问题。其病因包括色素性、结构性、血管性和混合性。
系统回顾 POH 的现有文献，以寻找治疗方法。
在 PubMed 上进行了系统的文献检索。检索词包括“眶周黑眼圈”、“黑眼圈”、“眶周皮肤色素沉着”、“特发性色素沉着和眼眶”、“下眼睑黑眼圈”、“ICHOR（眼眶区域特发性皮肤色素沉着）”、“黑眼圈”和“治疗”以及“填充物”和“黑眼圈”。
共纳入 39 项研究。POH 的有效治疗方法包括激光、局部乳膏和血清、填充物、化学换肤、微针、富血小板血浆注射、眼睑成形术和常压氧疗。
由于体积损失，软组织填充物和自体脂肪移植是治疗黑眼圈最有效的方法。如果导致黑眼圈的原因是皮肤松弛过度，则最好进行眼睑成形术。各种局部乳膏和化学换肤对于基于色素的 POH 很有用，而激光对血管性和色素性黑眼圈均有轻度至中度益处。鉴于支持这些结果的高质量证据稀缺，建议应选择性解读。进一步研究 POH 的随机临床试验将很有帮助。
