Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Department of Gastroenterology and Hepatology, University of Colorado, Aurora, Colorado, USA.
Am J Transplant. 2021 Mar;21(3):1056-1067. doi: 10.1111/ajt.16229. Epub 2020 Sep 3.
Literature on living nondirected liver donation is sparse. The purpose of this study was to assess health-related quality of life (HR-QOL) in anonymous nondirected living liver donors (ND-LLDs). ND-LLDs at 3 centers: University of Alberta (n = 12), University of Colorado (n = 12), and University of Southern California (n = 12), were surveyed. Thirty donors (83%) responded to the Donor Quality of Life (USC DQLS) and Short-Form 36 (SF-36). Most respondents (n = 15, 50%) donated their left lateral segment, 27% right lobe, and 23% left lobe. The majority were female (67%) and mean age was 38.9 ± 11.2 years at donation. Median follow-up was 1.1 (interquartile range 0.4-3.3) years. Approximately 37% had previously donated a kidney. Eleven experienced ≥1 postoperative complication, with only 1 Clavien-Dindo IIIb. Most reported minimal impact on school or work performance, all felt positive or neutral about their overall health since donation, and none expressed postdonation regrets. No donor reported impacts on health insurability, and 3 of 4 respondents attempting to purchase life insurance postdonation were successful. ND-LLD SF-36 outcomes were similar to US population norms. Overall, ND-LLDs demonstrated acceptable HR-QOL after donation and are appropriate candidates for partial liver donation. Based on evaluation of donation impact, consideration should be given to postdonation support strategies.
关于非定向活体肝捐赠的文献资料很少。本研究旨在评估匿名非定向活体肝供者（ND-LLD）的健康相关生活质量（HR-QOL）。在 3 个中心评估了 ND-LLD：阿尔伯塔大学（n=12）、科罗拉多大学（n=12）和南加州大学（n=12）。30 名捐赠者（83%）对捐赠者生活质量（USC DQLS）和简短形式 36（SF-36）进行了调查。大多数应答者（n=15，50%）捐献了他们的左外侧段，27%捐献了右叶，23%捐献了左叶。大多数是女性（67%），捐赠时的平均年龄为 38.9±11.2 岁。中位随访时间为 1.1 年（四分位距 0.4-3.3）。大约 37%的人以前捐过肾。11 人经历了≥1 次术后并发症，只有 1 例 Clavien-Dindo IIIb。大多数人报告对学业或工作表现影响最小，所有捐赠后对自己的整体健康状况都感到积极或中立，没有人表示捐赠后有遗憾。没有捐赠者报告对健康保险的影响，4 名试图在捐赠后购买人寿保险的人中，有 3 人成功。ND-LLD SF-36 结果与美国人群正常值相似。总体而言，ND-LLD 捐赠后表现出可接受的 HR-QOL，是部分肝捐赠的合适候选者。基于对捐赠影响的评估，应考虑制定捐赠后的支持策略。
