A novel 3D-printed head phantom with anatomically realistic geometry and continuously varying skull resistivity distribution for electrical impedance tomography.

Phantom experiments are an important step for testing during the development of new hardware or imaging algorithms for head electrical impedance tomography (EIT) studies. However, due to the sophisticated anatomical geometry and complex resistivity distribution of the human head, constructing an accurate phantom for EIT research remains challenging, especially for skull modelling. In this paper, we designed and fabricated a novel head phantom with anatomically realistic geometry and continuously varying skull resistivity distribution based on 3D printing techniques. The skull model was constructed by simultaneously printing the distinct layers inside the skull with resistivity-controllable printing materials. The entire phantom was composed of saline skin, a 3D-printed skull, saline cerebrospinal fluid (CSF) and 3D-printed brain parenchyma. The validation results demonstrated that the resistivity of the phantom was in good agreement with that of human tissue and was stable over time, and the new phantom performed well in EIT imaging. This paper provides a standardized, efficient and reproducible method for the construction of a head phantom for EIT that could be easily adapted to other conditions for manufacturing head phantoms for brain function research, such as transcranial direct current stimulation (TDCS) and electroencephalography (EEG).