Bu Fang-Tian, Wang Ao, Zhu Yan, You Hong-Mei, Zhang Ya-Fei, Meng Xiao-Ming, Huang Cheng, Li Jun
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China.
The Key Laboratory of Anti-Inflammatory of Immune Medicines, Ministry of Education, Hefei, China.
Liver Int. 2020 Nov;40(11):2612-2626. doi: 10.1111/liv.14629. Epub 2020 Oct 13.
With advances in genome and transcriptome research technology, the function and mechanism of lncRNAs in physiological and pathological states have been gradually revealed. Nuclear Enriched Abundant Transcript 1 (NEAT1, a long non-coding RNA), a vital component of paraspeckles, plays an indispensable role in the formation and integrity of paraspeckles. Throughout the research history, NEAT1 is mostly aberrantly upregulated in various cancers, and high expression of NEAT1 often contributes to poor prognosis of patients. Notably, the role and mechanism of NEAT1 in liver diseases have been increasingly reported. NEAT1 accelerates the progression of non-alcoholic fatty liver disease (NAFLD), liver fibrosis and hepatocellular carcinoma, while exerting a protective role in the pathogenesis of acute-on-chronic liver failure by inhibiting the inflammatory response. In this review, we will elaborate on relevant studies on the different casting of NEAT1 in liver diseases, especially focusing on its regulatory mechanisms and new opportunities for alcoholic liver disease.
随着基因组和转录组研究技术的进步，长链非编码RNA（lncRNAs）在生理和病理状态下的功能及机制已逐渐被揭示。核富集丰富转录本1（NEAT1，一种长链非编码RNA）是旁斑的重要组成部分，在旁斑的形成和完整性中发挥着不可或缺的作用。在整个研究历程中，NEAT1在各种癌症中大多异常上调，其高表达往往导致患者预后不良。值得注意的是，NEAT1在肝脏疾病中的作用和机制的报道越来越多。NEAT1加速非酒精性脂肪性肝病（NAFLD）、肝纤维化和肝细胞癌的进展，同时通过抑制炎症反应在慢加急性肝衰竭的发病机制中发挥保护作用。在这篇综述中，我们将详细阐述关于NEAT1在肝脏疾病中不同作用的相关研究，尤其关注其调控机制以及酒精性肝病的新机遇。
