Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China.
Food Chem Toxicol. 2020 Nov;145:111649. doi: 10.1016/j.fct.2020.111649. Epub 2020 Aug 1.
Deoxynivalenol (DON), which is one of the most common mycotoxins produced by Fusarium species, is often found known to contaminated food and feed all around the world. It usually causes diarrhea, vomiting, and gastrointestinal inflammation in both humans and animals. At present, one promising method of dealing with this mycotoxin is to detoxify it biologically using microbes or enzymes. Some microorganisms have the ability to absorb or degrade mycotoxins before gastrointestinal absorption occurs. Many fungi and bacteria have been reported to be able to play a role in the biological detoxification of DON. In this review, the occurrence of DON in food and its toxic effects are presented and the mechanisms by which DON can be detoxified biologically are also discussed. Then, the progress made in detoxifying DON in recent years using fungi, bacteria, and enzymes is summarized in more detail. Future developments relating to DON detoxification are also evaluated. The overall purpose of this paper is to provide a reliable reference source for the biological detoxification of DON.
脱氧雪腐镰刀菌烯醇（DON）是镰刀菌属产生的最常见的霉菌毒素之一，在全世界范围内，它通常存在于污染的食物和饲料中。DON 会导致人类和动物腹泻、呕吐和胃肠道炎症。目前，一种有前途的处理这种霉菌毒素的方法是使用微生物或酶进行生物解毒。一些微生物具有在胃肠道吸收之前吸收或降解霉菌毒素的能力。已经报道了许多真菌和细菌能够在 DON 的生物解毒中发挥作用。在这篇综述中，介绍了 DON 在食品中的发生及其毒性作用，并讨论了 DON 可以通过生物解毒的机制。然后，更详细地总结了近年来使用真菌、细菌和酶脱除 DON 的研究进展。还评估了与 DON 解毒相关的未来发展。本文的总体目的是为 DON 的生物解毒提供可靠的参考资料。
