Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610064, PR China.
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610064, PR China.
Curr Opin Biotechnol. 2020 Dec;66:113-122. doi: 10.1016/j.copbio.2020.06.015. Epub 2020 Aug 1.
Efficient cross-presentation is pivotal for vaccination against cancer and infection by intracellular virus and bacteria. Recently, various types of nanoparticle vaccines have been developed and investigated for efficiently and specifically improving cross-presentation and CD8 T cell priming. In this review, we will summarize the known intracellular pathways involved in cross-presentation, and focus on several nanoparticle strategies that have been reported for enhancing cross-presentation, including designing multifunctional nano-vaccines for increasing endosomal escape, designing nano-vaccines that can target lymph nodes to improve antigen uptake by lymph node resident CD8α dendritic cells, and co-delivering immune modulators for upregulating cross-presentation related intracellular components. We will also briefly discuss the future prospects of cross-presentation based nano-vaccine strategy for curing diseases.
有效的交叉呈递对于预防癌症和细胞内病毒和细菌感染的疫苗接种至关重要。最近，已经开发并研究了各种类型的纳米颗粒疫苗，以有效地和特异性地改善交叉呈递和 CD8 T 细胞的启动。在这篇综述中，我们将总结已知的涉及交叉呈递的细胞内途径，并重点介绍几种已报道的增强交叉呈递的纳米颗粒策略，包括设计多功能纳米疫苗以增加内体逃逸，设计能够靶向淋巴结以提高淋巴结驻留 CD8α 树突状细胞摄取抗原的纳米疫苗，以及共同递送免疫调节剂以上调与交叉呈递相关的细胞内成分。我们还将简要讨论基于纳米疫苗策略的交叉呈递治疗疾病的未来前景。
