Molecular Drug Metabolism and Toxicology Laboratories, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan 200005, Nigeria.
Cancer Research and Molecular Biology Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan 200005, Nigeria.
Exp Biol Med (Maywood). 2020 Oct;245(16):1490-1503. doi: 10.1177/1535370220947387. Epub 2020 Aug 3.
Infertility resulting from reproductive impairment is traumatic in families. Exposure to chemicals may play insidious roles not easily connected to infertility. We examined benzo[a]pyrene (BaP), and -methyl nitrosourea (NMU)-induced ovarian and uterine toxicity and the role of in mitigating toxicity. In a bid to illuminate folk medical claims cloaked in mystery, unearthing lost knowledge, advance natural chemopreventive agents, and report new evidence lacking in the literature attributed to . Although is known to exhibit anticonvulsant, antidiarrheal, antipyretic, antirheumatic, and analgesic effects in humans, its possible roles for mitigating toxicity stemming from inadvertent chemical exposures are reported here. Our findings affirm and further show that abates toxic response incumbent on oxidative damage and inflammatory responses associated with NMU and BaP exposure. Development of phytochemical derived from may serve as a potential natural therapy against chemical toxicities in individuals inadvertently exposed, and promote human health and reproductive satiety.
不孕不育给家庭带来创伤，生殖损伤导致的不孕不育尤为如此。化学物质的暴露可能会产生不易与不孕不育联系起来的隐性作用。我们研究了苯并[a]芘（BaP）和 N-甲基-N-亚硝基脲（NMU）引起的卵巢和子宫毒性，以及 在减轻毒性方面的作用。为了揭示神秘的民间医学说法，挖掘失落的知识，推进天然化学预防剂，并报告文献中缺乏的新证据，我们研究了 。尽管 已知在人类中具有抗惊厥、抗腹泻、解热、抗风湿和镇痛作用，但这里报告了其减轻因意外化学暴露引起的毒性的可能作用。我们的研究结果证实并进一步表明， 减轻了与 NMU 和 BaP 暴露相关的氧化损伤和炎症反应引起的毒性反应。从 中开发出的植物化学物质可能成为针对意外暴露于化学毒性的个体的潜在天然疗法，并促进人类健康和生殖满足。
