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Clinical and biological data on the use of hydroxychloroquine against SARS-CoV-2 could support the role of the NLRP3 inflammasome in the pathogenesis of respiratory disease.关于使用羟氯喹治疗新型冠状病毒肺炎的临床和生物学数据，可能支持NLRP3炎性小体在呼吸道疾病发病机制中的作用。
J Med Virol. 2021 Jan;93(1):124-126. doi: 10.1002/jmv.26217. Epub 2020 Jul 6.
2
Adjunct Immunotherapies for the Management of Severely Ill COVID-19 Patients.辅助免疫疗法治疗重症 COVID-19 患者。
Cell Rep Med. 2020 May 19;1(2):100016. doi: 10.1016/j.xcrm.2020.100016. Epub 2020 Apr 30.
3
In silico studies on the comparative characterization of the interactions of SARS-CoV-2 spike glycoprotein with ACE-2 receptor homologs and human TLRs.基于 SARS-CoV-2 刺突糖蛋白与 ACE-2 受体同源物和人类 TLR 相互作用的比较特征的计算机研究。
J Med Virol. 2020 Oct;92(10):2105-2113. doi: 10.1002/jmv.25987. Epub 2020 May 17.
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Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages.COVID-19 患者的病理性炎症：单核细胞和巨噬细胞的关键作用。
Nat Rev Immunol. 2020 Jun;20(6):355-362. doi: 10.1038/s41577-020-0331-4. Epub 2020 May 6.
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Design of a peptide-based subunit vaccine against novel coronavirus SARS-CoV-2.针对新型冠状病毒 SARS-CoV-2 的基于肽的亚单位疫苗设计。
Microb Pathog. 2020 Aug;145:104236. doi: 10.1016/j.micpath.2020.104236. Epub 2020 May 4.
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COVID-19: towards understanding of pathogenesis.新型冠状病毒肺炎：对发病机制的认识
Cell Res. 2020 May;30(5):367-369. doi: 10.1038/s41422-020-0327-4.
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SARS-CoV-2 and viral sepsis: observations and hypotheses.SARS-CoV-2 与病毒败血症：观察与假说。
Lancet. 2020 May 9;395(10235):1517-1520. doi: 10.1016/S0140-6736(20)30920-X. Epub 2020 Apr 17.
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Development of epitope-based peptide vaccine against novel coronavirus 2019 (SARS-COV-2): Immunoinformatics approach.基于表位的新型冠状病毒 2019（SARS-CoV-2）肽疫苗的研制：免疫信息学方法。
J Med Virol. 2020 Jun;92(6):618-631. doi: 10.1002/jmv.25736. Epub 2020 Mar 5.
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Toll-like receptor polymorphism in host immune response to infectious diseases: A review. Toll 样受体多态性与宿主抗感染免疫反应：综述。
Scand J Immunol. 2019 Jul;90(1):e12771. doi: 10.1111/sji.12771. Epub 2019 May 20.
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Toll-like receptors: promising therapeutic targets for inflammatory diseases. Toll 样受体：炎症性疾病有前景的治疗靶点。
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Targeting human TLRs to combat COVID-19: A solution?

作者信息

Patra Ritwik, Chandra Das Nabarun, Mukherjee Suprabhat

机构信息

Integrative Biochemistry & Immunology Laboratory, Department of Animal Science, Kazi Nazrul University, Asansol, West Bengal, India.

出版信息

J Med Virol. 2021 Feb;93(2):615-617. doi: 10.1002/jmv.26387. Epub 2020 Aug 13.

DOI:10.1002/jmv.26387
PMID:32749702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7436140/
Abstract
摘要