Department of Nursing, College of Health Science, Institute of Medicine and Health Science, Debre Berhan University, Ethiopia.
Department of Nursing, College of Health Science, Debre Markos University, Ethiopia.
Diabetes Metab Syndr. 2020 Sep-Oct;14(5):1403-1411. doi: 10.1016/j.dsx.2020.07.013. Epub 2020 Jul 23.
Metabolic syndrome is one of the serious public health problems among type 2 diabetic patients. Despite a number of studies have been conducted, there is no overall estimation on the prevalence of metabolic syndrome among type 2 diabetic patients in Sub-Saharan African countries. Therefore, this study aimed to estimate the pooled prevalence of metabolic syndrome in patients with type 2 diabetes mellitus in Sub -Saharan African countries.
PubMed, Web of Science, African Journals Online, Google Scholar, Scopus, and Wiley Online Library databases from inception to April 27, 2020 were searched to identify relevant studies. The I statistic was used to check heterogeneity across the included studies. DerSimonian and Laird random-effects model was applied to estimate pooled effect size, and 95% confidence interval across studies. A funnel plot and Egger's regression test were used to determine the presence of publication bias. Sensitivity analysis was deployed to determine the effect of a single study on the overall estimation. All statistical analyses were done using STATA™ Version 14 software.
In this meta-analysis, a total of 23 studies with 6482 study participants were included. The estimated prevalence of metabolic syndrome in Sub-Saharan African countries was 59.62% (95% CI: 52.20, 67.03). Based on the subgroup analysis, the highest prevalence of metabolic syndrome (61.14%, 95% CI: 51.74, 70.53) was reported in Ethiopia. Additionally, the highest prevalence of metabolic syndrome was reported across studies using the diagnostic criteria of National Cholesterol Education Program Adult Treatment Panel III 64.8% (95% CI: 54.74, 74.86), followed by International Diabetic Federation (57.15%), and World health Organization (53.12%) definitions.
Almost two out of three type 2 diabetic patients in Sub-Saharan African countries have metabolic syndrome, which implies that its prevalence is high in patients with type 2 diabetes mellitus. Therefore, policymakers need to design efficient strategies and guideline to reduce and control the burden of metabolic syndrome and its impact among diabetic population.
代谢综合征是 2 型糖尿病患者面临的严重公共卫生问题之一。尽管已经进行了多项研究，但在撒哈拉以南非洲国家，尚未对 2 型糖尿病患者代谢综合征的总体患病率进行评估。因此，本研究旨在评估撒哈拉以南非洲国家 2 型糖尿病患者代谢综合征的患病率。
检索了 PubMed、Web of Science、African Journals Online、Google Scholar、Scopus 和 Wiley Online Library 数据库，检索时间从建库至 2020 年 4 月 27 日，以确定相关研究。使用 I ² 统计量来评估纳入研究之间的异质性。采用 DerSimonian 和 Laird 随机效应模型来估计研究间的合并效应大小和 95%置信区间。采用漏斗图和 Egger 回归检验来评估发表偏倚的存在。进行敏感性分析以确定单个研究对总体估计的影响。所有统计分析均使用 STATA 版本 14 软件进行。
本荟萃分析共纳入 23 项研究，包含 6482 名研究对象。撒哈拉以南非洲国家代谢综合征的估计患病率为 59.62%（95%CI：52.20，67.03）。基于亚组分析，埃塞俄比亚报道的代谢综合征患病率最高（61.14%，95%CI：51.74，70.53）。此外，采用美国国家胆固醇教育计划成人治疗专家组第三版（64.8%，95%CI：54.74，74.86）诊断标准的研究中报告的代谢综合征患病率最高，其次是国际糖尿病联盟（57.15%）和世界卫生组织（53.12%）的定义。
撒哈拉以南非洲国家近三分之二的 2 型糖尿病患者患有代谢综合征，这表明该地区 2 型糖尿病患者的代谢综合征患病率较高。因此，政策制定者需要制定有效的策略和指南，以减轻和控制代谢综合征及其对糖尿病患者的影响。
