Vita - Salute San Raffaele University, via Olgettina 60, 20132 Milano, Italy.
Vita - Salute San Raffaele University, via Olgettina 60, 20132 Milano, Italy; Division of Immunology, Transplantation and Infectious Diseases, via Olgettina 60, 20132 Milano, Italy.
Pharmacol Res. 2020 Nov;161:105114. doi: 10.1016/j.phrs.2020.105114. Epub 2020 Aug 3.
Coronavirus Disease 2019 (COVID-19) is a pandemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical spectrum of COVID-19 is broad and varies from mild to severe forms complicated by acute respiratory distress and death. This heterogeneity might reflect the ability of the host immune system to interact with SARS-CoV2 or the characteristics of the virus itself in terms of loads or persistence. Information on this issue might derive from interventional studies. However, results from high-quality trials are scarce. Here we evaluate the level of evidence of available published interventional studies, with a focus on randomised controlled trials and the efficacy of therapies on clinical outcomes. Moreover, we present data on a large cohort of well-characterized patients hospitalized at a single University Hospital in Milano (Italy), correlating viral clearance with clinical and biochemical features of patients.
2019 年冠状病毒病（COVID-19）是由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起的大流行疾病。COVID-19 的临床谱广泛，从轻症到重症，重症可并发急性呼吸窘迫和死亡。这种异质性可能反映了宿主免疫系统与 SARS-CoV2 的相互作用能力，或者病毒本身在负荷或持续时间方面的特征。关于这个问题的信息可能来自干预性研究。然而，高质量试验的结果却很少。在这里，我们评估了现有发表的干预性研究的证据水平，重点是随机对照试验和治疗对临床结局的疗效。此外，我们还提供了在米兰（意大利）一家大学附属医院住院的大量特征良好的患者的数据，将病毒清除与患者的临床和生化特征相关联。
