Roberts Michael D, Haun Cody T, Vann Christopher G, Osburn Shelby C, Young Kaelin C
School of Kinesiology, Auburn, AL, United States.
Department of Cell Biology and Physiology, Edward Via College of Osteopathic Medicine - Auburn Campus, Auburn, AL, United States.
Front Physiol. 2020 Jul 14;11:816. doi: 10.3389/fphys.2020.00816. eCollection 2020.
Skeletal muscle fibers are multinucleated cells that contain mostly myofibrils suspended in an aqueous media termed the sarcoplasm. Select evidence suggests sarcoplasmic hypertrophy, or a disproportionate expansion of the sarcoplasm relative to myofibril protein accretion, coincides with muscle fiber or tissue growth during resistance training. There is also evidence to support other modes of hypertrophy occur during periods of resistance training including a proportional accretion of myofibril protein with fiber or tissue growth (i.e., conventional hypertrophy), or myofibril protein accretion preceding fiber or tissue growth (i.e., myofibril packing). In this review, we discuss methods that have been used to investigate these modes of hypertrophy. Particular attention is given to sarcoplasmic hypertrophy throughout. Thus, descriptions depicting this process as well as the broader implications of this phenomenon will be posited. Finally, we propose future human and rodent research that can further our understanding in this area of muscle physiology.
骨骼肌纤维是多核细胞，其中大部分肌原纤维悬浮在称为肌浆的水性介质中。有证据表明，肌浆肥大，即肌浆相对于肌原纤维蛋白增加的不成比例的扩张，与抗阻训练期间的肌纤维或组织生长同时发生。也有证据支持在抗阻训练期间发生其他肥大模式，包括肌原纤维蛋白与纤维或组织生长成比例增加（即传统肥大），或肌原纤维蛋白在纤维或组织生长之前增加（即肌原纤维堆积）。在这篇综述中，我们讨论了用于研究这些肥大模式的方法。全文特别关注肌浆肥大。因此，将阐述描述这一过程以及这一现象更广泛影响的内容。最后，我们提出未来的人体和啮齿动物研究，以进一步加深我们对肌肉生理学这一领域的理解。
