Li Zhongshan, Li Wenhao, Bai Shi, Yang Tieli
School of Sports Science, Fujian Normal University, Fuzhou, Fujian, China.
Department of Physical Education, Northeastern University, Shenyang, Liaoning, China.
Front Med (Lausanne). 2025 Jul 21;12:1614054. doi: 10.3389/fmed.2025.1614054. eCollection 2025.
Low-frequency pulse magnetic fields (PEMF) has been proven by classic transient receptor potential channel 1 (TRPC 1) transcription activation peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) increase upstream of the mitochondria calcium - axis to increase muscle and mitochondria function, and recreates the consistent with exercise induced metabolic adaptations and power to ascend.
Eighty healthy subjects with a mean age of 20 years were recruited and randomly divided into a PEMF group receiving magnetic field stimulation and a control group receiving sham treatment, with 40 patients in each group. The trial lasted for 4 weeks. Both groups were subjected to either a 15 min magnetic stimulation intervention or a sham treatment every 48 h. B-mode ultrasound images were used to evaluate changes in muscle thickness, cross-sectional area, pennation angle, and stiffness.
The PEMF group showed a significant increase in the MVC (maximum voluntary contraction) value and a significantly higher amplitude of the increase than the control group. There was no significant difference in BMI (Body Mass Index) between the two groups before and after the trial, nor in the rate of change in BMI between the two groups. However, from the analysis of the change trends, the PEMF group showed a downward trend, while the control group showed an increasing trend. In the PEMF group, all four parameters of muscle morphology were significantly higher than pre-test, while in the control group, all but one of the muscle stiffness metrics were significantly lower. The PEMF group had significantly higher muscle morphological parameters than did the control group.
The current clinical trial showed that in healthy individuals aged 20 years, after 4 weeks of chronic exposure to a low-frequency pulsed magnetic field (1.5 mT, 3,300 Hz), the maximum voluntary contraction force of the biceps brachii muscle was significantly increased, and a contralateral effect was observed. At the same time, the muscle thickness, cross-sectional area, pennation, and stiffness of the intervention arm increased significantly. It provides a supportive basis for the improvement of muscle histopathology using this technique as an exercise replacement and a medical strategy for muscle improvement.
[https://www.chictr.org.cn], identifier: [ChiCTR2300078947].
低频脉冲磁场（PEMF）已被证实可通过经典瞬时受体电位通道1（TRPC 1）转录激活过氧化物酶体增殖物激活受体γ共激活因子1α（PGC-1α），增加线粒体钙轴上游水平，从而增强肌肉和线粒体功能，并重现与运动诱导的代谢适应和力量提升相一致的效果。
招募80名平均年龄为20岁的健康受试者，随机分为接受磁场刺激的PEMF组和接受假治疗的对照组，每组40例患者。试验持续4周。两组每48小时接受一次15分钟的磁刺激干预或假治疗。使用B型超声图像评估肌肉厚度、横截面积、羽状角和硬度的变化。
PEMF组的最大自主收缩（MVC）值显著增加，且增加幅度明显高于对照组。试验前后两组的体重指数（BMI）无显著差异，两组间BMI的变化率也无显著差异。然而，从变化趋势分析来看，PEMF组呈下降趋势，而对照组呈上升趋势。在PEMF组中，肌肉形态的所有四个参数均显著高于测试前，而在对照组中，除一项肌肉硬度指标外，其余指标均显著降低。PEMF组的肌肉形态参数显著高于对照组。
当前临床试验表明，在20岁的健康个体中，经过4周长期暴露于低频脉冲磁场（1.5 mT，3300 Hz）后，肱二头肌的最大自主收缩力显著增加，并观察到对侧效应。同时，干预侧手臂的肌肉厚度、横截面积、羽状化和硬度均显著增加。这为使用该技术替代运动来改善肌肉组织病理学以及作为改善肌肉的医学策略提供了支持依据。
