Gao Yanxia, Gao Kexin, Yang Hui
Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Cell Regen. 2020 Aug 6;9(1):12. doi: 10.1186/s13619-020-00044-6.
The rapidly developmental RNA-guided CRISPR/Cas system is a powerful tool for RNA and DNA editing in a variety of cells from different species and makes a great contribution to gene function research, disease model generation and gene therapy development in the past few years. The ease of use, low cost and high efficiency of CRISPR/Cas make it commonly used in various conditions. In this review, we introduce the CRISPR/Cas system and its diverse applications in nervous system briefly, which provides a better understanding for its potential application values.
快速发展的RNA引导的CRISPR/Cas系统是一种用于对来自不同物种的多种细胞中的RNA和DNA进行编辑的强大工具，在过去几年中对基因功能研究、疾病模型构建和基因治疗发展做出了巨大贡献。CRISPR/Cas的易用性、低成本和高效率使其在各种情况下都得到广泛应用。在本综述中，我们简要介绍了CRISPR/Cas系统及其在神经系统中的多种应用，这有助于更好地理解其潜在的应用价值。
