Gouveia Flavia Venetucci, Germann Jürgen, Devenyi Gabriel A, Morais Rosa M C B, Santos Ana Paula M, Fonoff Erich T, Hamani Clement, Brentani Helena, Chakravarty M Mallar, Martinez Raquel C R
Sunnybrook Research Institute, Canada; and Hospital Sirio-Libanes, Brazil.
University Health Network; and CIC, Douglas Mental Health University Institute, McGill University, Canada.
BJPsych Open. 2020 Aug 7;6(5):e85. doi: 10.1192/bjo.2020.71.
Aggressive behaviour is a highly prevalent and devastating condition in autism spectrum disorder resulting in impoverished quality of life. Gold-standard therapies are ineffective in about 30% of patients leading to greater suffering. We investigated cortical thickness in individuals with autism spectrum disorder with pharmacological-treatment-refractory aggressive behaviour compared with those with non-refractory aggressive behaviour and observed a brain-wide pattern of local increased thickness in key areas related to emotional control and overall decreased cortical thickness in those with refractory aggressive behaviour, suggesting refractoriness could be related to specific morphological patterns. Elucidating the neurobiology of refractory aggressive behaviour is crucial to provide insights and potential avenues for new interventions.
攻击性行为是自闭症谱系障碍中一种高度普遍且具有破坏性的状况，会导致生活质量下降。金标准疗法在约30%的患者中无效，导致更多痛苦。我们研究了患有药物治疗难治性攻击性行为的自闭症谱系障碍个体与非难治性攻击性行为个体的皮质厚度，观察到与情绪控制相关的关键区域存在全脑范围的局部增厚模式，而难治性攻击性行为个体的皮质厚度总体下降，这表明难治性可能与特定的形态学模式有关。阐明难治性攻击性行为的神经生物学对于提供新干预措施的见解和潜在途径至关重要。
