Department of Psychiatry & Neuropsychiatric Genetics Research Group, School of Medicine, The Trinity Centre for Health Sciences, Trinity College Dublin, Dublin 8, Ireland.
J Autism Dev Disord. 2019 Oct;49(10):4209-4218. doi: 10.1007/s10803-019-04129-3.
Aggressive behaviour is a significant issue for individuals with autism spectrum disorder (ASD), yet our understanding is limited compared to aggression in typically developing populations. This study examined behavioural, adaptive and cognitive data provided by the Simons Simplex Collection (N = 2184) to identify behavioural subgroups in children and adolescents with ASD using latent profile analysis. Results showed five subgroups that differed with regards to behavioural severity, IQ and adaptive behaviour. In two profiles with higher aggression, individuals had greater comorbid anxiety symptoms and attentional deficits and also differed in adaptive behaviour and IQ. These results identify potentially important avenues for research in aggressive behaviour in ASD.
攻击性行为是自闭症谱系障碍（ASD）个体的一个重大问题，但与典型发育人群的攻击性相比，我们的了解有限。本研究使用潜在剖面分析，根据西蒙斯单纯型集合（N=2184）提供的行为、适应和认知数据，来确定 ASD 儿童和青少年的行为亚组。结果显示，五个亚组在行为严重程度、智商和适应行为方面存在差异。在两个攻击性较高的特征中，个体存在更多的共患焦虑症状和注意力缺陷，并且在适应行为和智商方面也存在差异。这些结果确定了 ASD 中攻击性行为研究的潜在重要方向。
