Analysis of Protein-Targeting in the Nucleus of Host Cells and the Implications in Colon Cancer: An in-silico Approach.

BACKGROUND

Infections of () are major threats to health, threats include diarrhoea, fever, acute intestinal inflammation, and cancer. Nevertheless, little information is available about the involvement of in colon cancer etiology.

METHODS

The present study was designed to predict nuclear targeting of proteins in the host cell through computational tools, including nuclear localization signal (NLS) mapper, Balanced Subcellular Localization predictor (BaCeILo), and Hum-mPLoc using next-generation sequencing data.

RESULTS

Several gene expression-associated proteins of have been predicted to target the host nucleus during intracellular infections. Nuclear targeting of proteins can lead to competitive interactions between the host and pathogen proteins with similar cellular substrates, and it may have a possible involvement in colon cancer growth. Our results suggested that releases its proteins within compartments of the host cell, where they act as a component of the host cell proteome. Protein targeting is possibly involved in colon cancer etiology during intracellular bacterial infection.

CONCLUSION

The results of current in-silico study showed the potential involvement of infection with alteration in normal functioning of host cell which act as possible factor to connect with the growth and development of colon cancer.