Li Jianhua, Zakariah Mohammed, Malik Abdul, Ola Mohammad Shamsul, Syed Rabbani, Chaudhary Anis Ahmad, Khan Shahanavaj
Department of General Surgery Ⅰ, Xinxiang Central Hospital, Xinxiang City, Henan Province 453000, People's Republic of China.
Research Center, College of Computer and Information Science, King Saud University, Riyadh, Saudi Arabia.
Infect Drug Resist. 2020 Jul 20;13:2433-2442. doi: 10.2147/IDR.S258037. eCollection 2020.
Infections of () are major threats to health, threats include diarrhoea, fever, acute intestinal inflammation, and cancer. Nevertheless, little information is available about the involvement of in colon cancer etiology.
The present study was designed to predict nuclear targeting of proteins in the host cell through computational tools, including nuclear localization signal (NLS) mapper, Balanced Subcellular Localization predictor (BaCeILo), and Hum-mPLoc using next-generation sequencing data.
Several gene expression-associated proteins of have been predicted to target the host nucleus during intracellular infections. Nuclear targeting of proteins can lead to competitive interactions between the host and pathogen proteins with similar cellular substrates, and it may have a possible involvement in colon cancer growth. Our results suggested that releases its proteins within compartments of the host cell, where they act as a component of the host cell proteome. Protein targeting is possibly involved in colon cancer etiology during intracellular bacterial infection.
The results of current in-silico study showed the potential involvement of infection with alteration in normal functioning of host cell which act as possible factor to connect with the growth and development of colon cancer.
（某病原体，原文未明确写出具体名称）感染是对健康的主要威胁，这些威胁包括腹泻、发热、急性肠道炎症和癌症。然而，关于（该病原体）在结肠癌病因学中的作用，目前所知甚少。
本研究旨在通过计算工具，利用下一代测序数据预测宿主细胞中（该病原体）蛋白质的核靶向，这些工具包括核定位信号（NLS）映射器、平衡亚细胞定位预测器（BaCeILo）和人类蛋白质定位工具（Hum-mPLoc）。
在细胞内感染期间，已预测（该病原体）的几种与基因表达相关的蛋白质会靶向宿主细胞核。（该病原体）蛋白质的核靶向可导致宿主和病原体蛋白质之间与相似细胞底物的竞争性相互作用，并且可能参与结肠癌的生长。我们的结果表明，（该病原体）在宿主细胞的区室中释放其蛋白质，在那里它们作为宿主细胞蛋白质组的一个组成部分发挥作用。蛋白质靶向可能在细胞内细菌感染期间参与结肠癌的病因学。
当前的计算机模拟研究结果表明，（该病原体）感染可能参与宿主细胞正常功能的改变，这可能是与结肠癌生长和发展相关的一个因素。
