Oh Eunkyoung, Kim Youjin, Park Soo-Yeon, Lim Yeni, Shin Ji-Yoon, Kim Ji Yeon, Kim Ji-Hyun, Rhee Moo-Yong, Kwon Oran
Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 03760, Korea.
Ewha Graduate School of Converging Clinical & Public Health, Seoul 03760, Korea.
Nutr Res Pract. 2020 Aug;14(4):322-333. doi: 10.4162/nrp.2020.14.4.322. Epub 2020 Mar 30.
BACKGROUND/OBJECTIVES: Arterial stiffness and endothelial dysfunction are 2 of the independent predictors for cardiovascular disease, while (ASH) is a traditional medicinal plant that can improve cardiovascular health. This study aimed to investigate the efficacy of the fruit of ASH on vascular function in apparently healthy subjects.
SUBJECTS/METHODS: A 12-week, randomized, double-blind, placebo-controlled design, consisting of healthy adults with at least 2 of the following 3 conditions: borderline high blood pressure (BP; 120 mmHg ≤ systolic BP ≤ 160 mmHg or 80 mmHg ≤ diastolic BP ≤ 100 mmHg), smoking (≥10 cigarettes/day), and borderline blood lipid levels (220 ≤ total cholesterol ≤ 240, 130 ≤ low density lipoprotein cholesterol ≤ 165, or 150 ≤ triglyceride ≤ 220 mg/dL). Randomly assigned 76 subjects who received a placebo or 2 doses of ASH fruit (low, 500 mg/day; high, 1,000 mg/day) completed the intervention. Brachial-ankle pulse wave velocity (baPWV), flow-mediated dilation, carotid intima-media thickness, and BP were measured both at baseline and following the 12-week intervention. Endothelial nitric oxide synthase (eNOS) phosphorylation was assessed by western blotting.
Compared with the placebo group, the low-dose group showed more significant changes after the 12-week intervention period in terms of systolic BP (0.1 vs. -7.7 mmHg; = 0.044), baPWV (31.3 vs. -98.7 cm/s; = 0.007), and the ratio of phospho-eNOS/eNOS (0.8 vs. 1.22; = 0.037).
These results suggest that ASH fruit extract at 500 mg/day has the potential to improve BP and arterial stiffness via endothelial eNOS activation in healthy adults with smoking and the tendency of having elevated BP or blood lipid parameters.
Clinical Research Information Service Identifier: KCT0001072.
背景/目的：动脉僵硬度和内皮功能障碍是心血管疾病的两个独立预测因素，而（某药用植物名称未给出，暂用ASH表示）是一种可改善心血管健康的传统药用植物。本研究旨在调查ASH果实对表面健康受试者血管功能的功效。
受试者/方法：采用为期12周的随机、双盲、安慰剂对照设计，受试者为至少具备以下3种情况中2种的健康成年人：临界高血压（收缩压120 mmHg≤收缩压≤160 mmHg或舒张压80 mmHg≤舒张压≤100 mmHg）、吸烟（≥10支/天）和临界血脂水平（总胆固醇220≤总胆固醇≤240、低密度脂蛋白胆固醇130≤低密度脂蛋白胆固醇≤165或甘油三酯150≤甘油三酯≤220 mg/dL）。随机分配76名接受安慰剂或2种剂量ASH果实（低剂量，500 mg/天；高剂量，1000 mg/天）的受试者完成干预。在基线和12周干预后测量肱踝脉搏波速度（baPWV）、血流介导的血管舒张、颈动脉内膜中层厚度和血压。通过蛋白质免疫印迹法评估内皮型一氧化氮合酶（eNOS）磷酸化。
与安慰剂组相比，低剂量组在12周干预期后，收缩压（0.1对-7.7 mmHg；P = 0.044）、baPWV（31.3对-98.7 cm/s；P = 0.007）以及磷酸化eNOS/eNOS比值（0.8对1.22；P = 0.037）方面显示出更显著的变化。
这些结果表明，对于有吸烟习惯且有血压或血脂参数升高倾向的健康成年人，每天500 mg的ASH果实提取物有可能通过激活内皮eNOS来改善血压和动脉僵硬度。
临床研究信息服务标识符：KCT0001072。
