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新型冠状病毒肺炎与衰老疗法：天然存在的二肽肌肽有何作用？

COVID-19 and Senotherapeutics: Any Role for the Naturally-occurring Dipeptide Carnosine?

作者信息

Hipkiss Alan R

机构信息

Aston Research Centre for Healthy Ageing (ARCHA), Aston University, Birmingham, B4 7ET, UK.

出版信息

Aging Dis. 2020 Jul 23;11(4):737-741. doi: 10.14336/AD.2020.0518. eCollection 2020 Jul.

DOI:10.14336/AD.2020.0518
PMID:32765939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7390525/
Abstract

It is suggested that the non-toxic dipeptide carnosine (beta-alanyl-L-histidine) should be examined as a potential protective agent against COVID-19 infection and inflammatory consequences especially in the elderly. Carnosine is an effective anti-inflammatory agent which can also inhibit CD26 and ACE2 activity. It is also suggested that nasal administration would direct the peptide directly to the lungs and escape the attention of serum carnosinase.

摘要

有人建议，无毒二肽肌肽（β-丙氨酰-L-组氨酸）应作为一种潜在的保护剂，用于预防新型冠状病毒肺炎感染及其炎症后果，尤其是在老年人中。肌肽是一种有效的抗炎剂，还能抑制CD26和血管紧张素转换酶2（ACE2）的活性。还有人建议，鼻腔给药可使该肽直接进入肺部，从而避开血清肌肽酶的作用。

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