Department of Gastroenterology, Nottingham Digestive Diseases Centre, Nottingham University Hospitals NHS, Nottingham, UK.
GI Unit, 3rd Department of Internal Medicine, National & Kapodistrian University of Athens, Sotiria Hospital, Athens, Greece.
Inflamm Bowel Dis. 2021 May 17;27(6):826-835. doi: 10.1093/ibd/izaa201.
Fatigue is highly prevalent among patients with inflammatory bowel disease (IBD) and may have an unfavorable impact on quality of life (QoL). The IBD-Fatigue scale (with components SCORE1 and SCORE2) is a recently developed disease-specific questionnaire. We sought to validate a Greek version of IBD-F and use it to assess the severity and characteristics of fatigue and its effect on QoL in our study population.
The IBD-F scale was validated and used to obtain fatigue-related data from patients with IBD attending a tertiary care hospital. Correlations with other fatigue and QoL instruments were performed.
The Greek IBD-F showed high internal consistency and test-retest reliability (Cronbach's alpha = 0.901/0.966 and intraclass correlation coefficient = 0.876/0.895 for SCORE1/SCORE2, respectively). A SCORE1 >7.5 suggested "significant" fatigue. In a cohort of 157 patients (mean age = 35.8 y; male patients = 52.2%; patients with Crohn disease = 65.6%), both SCORE1 and SCORE2 were significantly associated with Crohn disease (odds ratio [OR] = 4.17; 95% confidence interval [CI], 2.05-8.47; b = 8.5; 95% CI, 2.8-14.1, respectively), female sex (OR = 7.27; 95% CI, 3.19-16.6; b = 15.3; 95% CI, 9-21.6), and Harvey-Bradshaw Index/Simple Clinical Colitis Activity Index score (OR = 1.22; 95% CI, 1.06-1.39; b = 1.8; 95% CI, 0.9-2.8). A SCORE1 >7.5 was present in 46% of patients in remission, and 82% of patients with a baseline SCORE1 >7.5 remained fatigued at serial measurements. The SCORE1 was significantly associated with impaired QoL (P < 0.001).
The validated IBD-F scale is a useful and applicable instrument for use in the IBD population. A large proportion of patients have significant fatigue, which is maintained longitudinally, independent of inflammatory activity. Fatigue impairs QoL, thus necessitating interventions that may lead to its amelioration in the IBD population.
炎症性肠病（IBD）患者普遍存在疲劳症状，且可能对生活质量（QoL）产生不利影响。IBD 疲劳量表（包含 SCORE1 和 SCORE2 两个分量）是一种最近开发的针对特定疾病的问卷。我们旨在验证希腊语版 IBD-F 量表，并使用其评估研究人群中疲劳的严重程度和特征及其对 QoL 的影响。
对在三级保健医院就诊的 IBD 患者进行 IBD-F 量表的验证，并获取与疲劳相关的数据。同时还对其与其他疲劳和 QoL 量表的相关性进行了分析。
希腊语版 IBD-F 量表具有较高的内部一致性和重测信度（SCORE1 和 SCORE2 的 Cronbach's alpha 值分别为 0.901/0.966 和 0.876/0.895，组内相关系数分别为 0.876/0.895）。SCORE1 评分>7.5 提示存在“显著”疲劳。在 157 例患者（平均年龄 35.8 岁；男性占 52.2%；克罗恩病患者占 65.6%）的队列中，SCORE1 和 SCORE2 均与克罗恩病显著相关（比值比 [OR] = 4.17；95%置信区间 [CI]，2.05-8.47；b = 8.5；95% CI，2.8-14.1），与女性（OR = 7.27；95% CI，3.19-16.6；b = 15.3；95% CI，9-21.6）和 Harvey-Bradshaw 指数/简单临床结肠炎活动指数评分（OR = 1.22；95% CI，1.06-1.39；b = 1.8；95% CI，0.9-2.8）相关。缓解期患者中，46%存在 SCORE1 >7.5，基线 SCORE1 >7.5 的患者中有 82%在连续测量中仍存在疲劳。SCORE1 与 QoL 受损显著相关（P < 0.001）。
验证后的 IBD-F 量表是一种在 IBD 人群中有用且适用的工具。很大一部分患者存在显著的疲劳，且这种疲劳具有纵向持续性，与炎症活动无关。疲劳会损害 QoL，因此需要干预措施，以改善 IBD 人群的疲劳症状。
