(Instituto de Biotecnología-IABIMO, INTA-CONICET), Institute of Biotechnology-IABIMO, National Institute of Agricultural Technology (INTA) and National Scientific and Technical Research Council (CONICET), Argentina.
(Universidad de Buenos Aires, Facultad de Agronomía), University of Buenos Aires, School of Agronomy Facultad de Agronomía, UBA, Buenos Aires Argentina.
Vet Microbiol. 2020 Aug;247:108758. doi: 10.1016/j.vetmic.2020.108758. Epub 2020 Jun 21.
Members of the Mycobacterium tuberculosis complex (MTBC) are responsible for tuberculosis in several mammals. In this complex, Mycobacterium tuberculosis and Mycobacterium bovis, which are closely related, show host preference for humans and cattle, respectively. Although human and bovine tuberculosis are clinically similar, M. tuberculosis mostly causes latent infection in humans, whereas M. bovis frequently leads to an acute infection in cattle. This review attempts to connect the pathology in experimental animal models as well as the cellular responses to M. bovis and M. tuberculosis regarding the differences in protein expression and regulatory mechanisms of both pathogens that could explain their apparent divergent latency behaviour. The occurrence of latent bovine tuberculosis (bTB) would represent a serious complication for the eradication of the disease in cattle, with the risk of onward transmission to humans. Thus, understanding the physiological events that may lead to the state of latency in bTB could assist in the development of appropriate prevention and control tools.
结核分枝杆菌复合体（MTBC）的成员可导致数种哺乳动物发生结核病。在该复合体中，与人类和牛分别具有亲和性的结核分枝杆菌和牛分枝杆菌显示出宿主偏好性。尽管人类和牛型结核病在临床上相似，但结核分枝杆菌在人类中主要引起潜伏感染，而牛分枝杆菌则常导致牛的急性感染。本综述试图将实验动物模型中的病理学以及针对牛分枝杆菌和结核分枝杆菌的细胞反应联系起来，研究两种病原体在蛋白表达和调控机制方面的差异，这些差异可以解释它们明显不同的潜伏行为。潜伏性牛型结核病（bTB）的发生将代表牛结核病根除工作中的一个严重并发症，存在向人类传播的风险。因此，了解可能导致 bTB 潜伏状态的生理事件，有助于开发适当的预防和控制工具。
