Abe Yuko, Hozumi Yutaka, Okamura Ken, Suzuki Tamio
Department of Dermatology, Yamagata University Faculty of Medicine, Yamagata, Japan.
J Dermatol. 2020 Nov;47(11):1330-1334. doi: 10.1111/1346-8138.15534. Epub 2020 Aug 8.
Vitiligo is a depigmentation disease characterized by gradual loss of melanin and melanocytes from the epidermis. The mechanism of melanocyte loss is not yet known. In this report, we showed that the expression of discoidin domain receptor 1 and E-cadherin, known adhesion molecules, was variable or absent in the epidermis of rhododendrol-induced leukoderma (RDIL) mice during the depigmentation process. Our findings suggest that melanocyte damage by rhododendrol promotes reduction of adhesion molecules not only in melanocytes but also in keratinocytes, and this is associated with the detachment of melanocytes from the basal layer.
白癜风是一种色素脱失性疾病，其特征是表皮中的黑色素和黑素细胞逐渐丧失。黑素细胞丧失的机制尚不清楚。在本报告中，我们表明，在杜鹃醇诱导的白斑病（RDIL）小鼠的表皮中，已知的粘附分子盘状结构域受体1和E-钙粘蛋白的表达在色素脱失过程中是可变的或缺失的。我们的研究结果表明，杜鹃醇对黑素细胞的损伤不仅促进了黑素细胞中粘附分子的减少，也促进了角质形成细胞中粘附分子的减少，这与黑素细胞从基底层的脱离有关。
