糖尿病视网膜病变患者中 VEGF、apelin 和 HO-1：相关性分析。
VEGF, apelin and HO-1 in diabetic patients with retinopathy: a correlation analysis.
机构信息
Department of Endocrinology, The Affiliated Hospital of Inner Mongolia Medical University, No.1st tunnel north road, Hohhot, 010000, Innermongolia, China.
出版信息
BMC Ophthalmol. 2020 Aug 8;20(1):326. doi: 10.1186/s12886-020-01593-9.
BACKGROUND
It's necessary to analyze the role of VEGF, apelin, and HO-1 in patients with type 2 diabetes (T2DM), and to evaluate its relevance to diabetic retinopathy (DR).
METHODS
T2DM patients who were treated in our hospital from December 1, 2018 to November 30, 2019 were included. T2DM patients were divided into non-DR (NDR) group, non-proliferative DR (NPDR) group, and proliferative DR (PDR) group. and healthy participants were selected as the control group. The value of VEGF, apelin, and HO1 in predicting PDR were analyzed by receiver operating characteristic (ROC) curve, and the relations of VEGF, apelin, HO-1 and clinical factors in PDR patients were analyzed by Pearson correlation analysis.
RESULTS
A total of 295 participants were included. The level of FPG and HbAlc in PDR group were significantly higher than that of other groups (all p < 0.05); the level of VEGF and apelin in PDR group were significantly higher than that of other groups (all p < 0.05), but the level of HO-1 in PDR group were significantly less than that of other groups(p = 0.017); the AUC of VEGF, apelin, HO-1 and combined use was 0.806(95%CI: 0.779-0.861), 0.819(95%CI: 0.765-0.878), 0.808(95%CI: 0.733-0.869) and 0.902(95%CI: 0.822-0.958) respectively, the AUC, sensitivity, specificity of the three combined use was significantly higher than that of single VEGF, apelin, HO-1 use(all p < 0.05). The cutoff values of serum VEGF, apelin, and HO-1 levels for predicting PDR were 163.85 pg/ml, 8.27 ng/ml, and 26.06 mmol/L respectively. Serum VEGF, apelin, and HO-1 in patients with PDR was related to the time course of DM, FPG and HbAlc (all p < 0.05).
CONCLUSIONS
VEGF, apelin and HO-1 are related to the progress of DR, and the combined use of VEGF, apelin and HO-1 is beneficial to the diagnosis and treatment of PDR.
背景
分析血管内皮生长因子（VEGF）、apelin 和血红素加氧酶-1（HO-1）在 2 型糖尿病（T2DM）患者中的作用，并评估其与糖尿病视网膜病变（DR）的相关性。
方法
选取 2018 年 12 月 1 日至 2019 年 11 月 30 日在我院治疗的 T2DM 患者。将 T2DM 患者分为非 DR（NDR）组、非增生性 DR（NPDR）组和增生性 DR（PDR）组。并选择健康参与者作为对照组。通过受试者工作特征（ROC）曲线分析 VEGF、apelin 和 HO1 对 PDR 的预测价值，通过 Pearson 相关分析分析 PDR 患者 VEGF、apelin、HO-1 与临床因素的关系。
结果
共纳入 295 名参与者。PDR 组的 FPG 和 HbAlc 水平明显高于其他组（均 p<0.05）；PDR 组 VEGF 和 apelin 水平明显高于其他组（均 p<0.05），但 PDR 组 HO-1 水平明显低于其他组（p=0.017）；VEGF、apelin、HO-1 和联合使用的 AUC 分别为 0.806（95%CI：0.779-0.861）、0.819（95%CI：0.765-0.878）、0.808（95%CI：0.733-0.869）和 0.902（95%CI：0.822-0.958），三种联合使用的 AUC、敏感性、特异性明显高于单独使用 VEGF、apelin、HO-1（均 p<0.05）。预测 PDR 的血清 VEGF、apelin 和 HO-1 水平的截断值分别为 163.85pg/ml、8.27ng/ml 和 26.06mmol/L。PDR 患者血清 VEGF、apelin 和 HO-1 与 DM 病程、FPG 和 HbAlc 有关（均 p<0.05）。
结论
VEGF、apelin 和 HO-1 与 DR 的进展有关，联合使用 VEGF、apelin 和 HO-1 有利于 PDR 的诊断和治疗。
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