Berber Reshid, Aziz Sheweidin, Simkins Joanna, Lin Sheldon S, Mangwani Jitendra
Academic Team of Musculoskeletal Surgery, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4PW, UK.
Department of Orthopaedics, Rutgers New Jersey Medical School, 90 Bergen Street, Newark, NJ, 07101, USA.
J Clin Orthop Trauma. 2020 Jul;11(Suppl 4):S500-S505. doi: 10.1016/j.jcot.2020.03.009. Epub 2020 Apr 21.
Low Intensity Pulsed Ultrasound Therapy (LIPUS) is a non-invasive treatment and aims to reduce fracture healing time and avoid non-union by delivering micro-mechanical stress to the bone to stimulate bone healing. In 2018, the National Institute for Health and Clinical Excellence (NICE) recommended that the evidence for LIPUS to promote healing of delayed-union and non-union fractures raised no major safety concerns, but the current evidence on efficacy is inadequate in quality. Little is known about the potential benefits of LIPUS for fracture healing in diabetic patients. In this article, we review the current evidence of LIPUS therapy both in animal and human studies and its possible application on fractures in diabetics.
低强度脉冲超声疗法（LIPUS）是一种非侵入性治疗方法，旨在通过向骨骼传递微机械应力以刺激骨愈合，从而缩短骨折愈合时间并避免骨不连。2018年，英国国家卫生与临床优化研究所（NICE）建议，有证据表明LIPUS促进延迟愈合和骨不连骨折的愈合不会引起重大安全问题，但目前关于疗效的证据质量不足。关于LIPUS对糖尿病患者骨折愈合的潜在益处知之甚少。在本文中，我们回顾了LIPUS疗法在动物和人体研究中的现有证据及其在糖尿病患者骨折中的可能应用。
