环状 RNA circHIPK3 通过 miR-637/STAT3 轴促进骨肉瘤细胞转移。
Circular RNA circHIPK3 Promotes Cell Metastasis through miR-637/STAT3 Axis in Osteosarcoma.
机构信息
Department of Orthopaedics, Minhang Hospital, Fudan University, 170 Xin-Song Road, Shanghai 201199, China.
Department of Pathology, Minhang Hospital, Fudan University, 170 Xin-Song Road, Shanghai 201199, China.
出版信息
Biomed Res Int. 2020 Jul 24;2020:2727060. doi: 10.1155/2020/2727060. eCollection 2020.
Abstract
Recent studies have suggested that circular RNAs play an important role in the progression of various cancers. However, few studies have revealed the great value of circRNAs in the diagnosis and prognosis prediction of osteosarcoma (OS). In this study, we performed experiments with the human OS cell lines and the results showed that the expression of circHIPK3 in OS cell lines was significantly upregulated compared to that in the normal cell line. In addition, the results showed that circHIPK3 could promote the migration, invasion, and growth of OS cells. Furthermore, miR-637 was identified as a target of circHIPK3, while STAT3 was targeted by miR-637. circHIPK3 could promote STAT3 expression via interacting with miR-637 in OS cells. In conclusion, our research uncovered an important role of the circHIPK3/miR-637/STAT3 pathway in the migration and invasion of OS cells and suggested that circHIPK3 may be a prognostic marker and a promising therapeutic target for OS.
摘要
最近的研究表明，环状 RNA 在各种癌症的进展中发挥着重要作用。然而，很少有研究揭示 circRNAs 在骨肉瘤 (OS) 的诊断和预后预测中的巨大价值。在这项研究中，我们对人骨肉瘤细胞系进行了实验，结果表明，与正常细胞系相比，circHIPK3 在骨肉瘤细胞系中的表达明显上调。此外，结果表明 circHIPK3 可以促进 OS 细胞的迁移、侵袭和生长。进一步研究表明，miR-637 是 circHIPK3 的靶标，而 STAT3 是 miR-637 的靶标。circHIPK3 可以通过与 OS 细胞中的 miR-637 相互作用来促进 STAT3 表达。总之，我们的研究揭示了 circHIPK3/miR-637/STAT3 通路在 OS 细胞迁移和侵袭中的重要作用，并表明 circHIPK3 可能是 OS 的一个预后标志物和有前途的治疗靶点。
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