Wei Zeyu, Shi Yijia, Xue Changning, Li Mengna, Wei Jianxia, Li Guiyuan, Xiong Wei, Zhou Ming
NHC Key Laboratory of Carcinogenesis, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China.
Xiangya Stomatological Hospital, Central South University, Changsha, Hunan 410078, China.
J Cancer. 2022 Nov 28;13(15):3674-3686. doi: 10.7150/jca.78090. eCollection 2022.
CircHIPK3 is a type of endogenous circular RNA, which contains a covalently closed circular structure and cannot encode protein or polypeptide. CircHIPK3 is unusually expressed in varieties of tumors and plays dual roles of tumor promotion or tumor inhibition in tumorigenesis and development of tumors by serving as the sponge for miRNA in multiple tumors. Here, we reviewed the differential expression, the dual functions, the regulation mechanism, and the network in a variety of tumors as well as the potential value for the diagnosis and treatment of tumors, which are of great significance for our comprehensive understanding of the roles and mechanisms of circHIPK3 in tumors.
环状HIPK3是一种内源性环状RNA，其含有共价闭合的环状结构，不能编码蛋白质或多肽。环状HIPK3在多种肿瘤中异常表达，并通过在多种肿瘤中作为miRNA的海绵，在肿瘤的发生和发展中发挥促进肿瘤或抑制肿瘤的双重作用。在此，我们综述了环状HIPK3在多种肿瘤中的差异表达、双重功能、调控机制、网络以及对肿瘤诊断和治疗的潜在价值，这对于我们全面了解环状HIPK3在肿瘤中的作用和机制具有重要意义。
