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咖啡对药物药代动力学性质的影响：综述。

The Effect of Coffee on Pharmacokinetic Properties of Drugs : A Review.

机构信息

Department of Pharmacy, College of Health Sciences, Debre Markos University, Ethiopia.

Department of Pharmaceutics, School of Pharmacy, College of Health Sciences, Mekelle University, Ethiopia.

出版信息

Biomed Res Int. 2020 Jul 24;2020:7909703. doi: 10.1155/2020/7909703. eCollection 2020.

DOI:10.1155/2020/7909703
PMID:32775441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7397437/
Abstract

BACKGROUND

Coffee has been the most commercialized food product and most widely consumed stimulant beverage in the world. It is a major source of caffeine which is the most bioactive component of coffee. Although both the United States Department of Agriculture and European Food Safety Authority consider daily intake of coffee which contains 400 mg of caffeine as safe for health, it causes different clinically significant pharmacokinetic interactions with many drugs. The aim of this work was to review the effect of coffee on the pharmacokinetic properties of drug

METHOD

This review was done by investigating the and research findings, clinical case reports, and expert panels from credible sources including Scopus, PubMed, Hindawi, OVID, Google Scholar, Embase, Cochrane Library, and Web of Science.

RESULT

Several studies and medical case reports evidently showed that concomitant consumption of coffee significantly affects the absorption, distribution, metabolism, and excretion of many drugs. These effects of coffee on the pharmacokinetics of drugs could lead to enhanced therapeutic response, therapeutic failure, or toxic reactions. . Concomitant use of coffee should be avoided with medications which have a significant interaction with coffee. There should be an appropriate time gap between intake of drugs and coffee based on drug properties. Pharmacists and clinicians should be aware of the potential risks of drug-coffee interaction and advice patients appropriately. Further and studies should be done for frequently prescribed drugs to get a strong evidence on the pharmacokinetic interaction with coffee.

摘要

背景

咖啡是全球商业化程度最高、消费最广泛的含咖啡因刺激性饮料，也是咖啡因的主要来源，咖啡因是咖啡中最具生物活性的成分。虽然美国农业部和欧洲食品安全局都认为，每天摄入含有 400 毫克咖啡因的咖啡对健康是安全的，但它会与许多药物产生不同的具有临床意义的药代动力学相互作用。这项工作的目的是综述咖啡对药物药代动力学特性的影响。

方法

本综述通过调查 和 研究结果、临床病例报告以及来自 Scopus、PubMed、Hindawi、OVID、Google Scholar、Embase、Cochrane Library 和 Web of Science 等可靠来源的专家小组进行。

结果

几项研究和医学病例报告清楚地表明，同时摄入咖啡会显著影响许多药物的吸收、分布、代谢和排泄。咖啡对药物药代动力学的这些影响可能导致治疗效果增强、治疗失败或毒性反应。因此，应避免同时使用与咖啡有显著相互作用的药物。根据药物特性，在摄入药物和咖啡之间应保持适当的时间间隔。药剂师和临床医生应意识到药物-咖啡相互作用的潜在风险，并为患者提供适当的建议。应进一步进行 和 研究，以获得关于与咖啡的药代动力学相互作用的常用处方药物的有力证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b86/7397437/5ffc0697c252/BMRI2020-7909703.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b86/7397437/297de2da251e/BMRI2020-7909703.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b86/7397437/2a7c2557e8f9/BMRI2020-7909703.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b86/7397437/0e31c28313fb/BMRI2020-7909703.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b86/7397437/bb6dcd30ef01/BMRI2020-7909703.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b86/7397437/5bb62a17cc56/BMRI2020-7909703.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b86/7397437/f322f29e797a/BMRI2020-7909703.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b86/7397437/28a331d53784/BMRI2020-7909703.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b86/7397437/402120446c52/BMRI2020-7909703.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b86/7397437/5ffc0697c252/BMRI2020-7909703.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b86/7397437/297de2da251e/BMRI2020-7909703.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b86/7397437/2a7c2557e8f9/BMRI2020-7909703.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b86/7397437/0e31c28313fb/BMRI2020-7909703.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b86/7397437/bb6dcd30ef01/BMRI2020-7909703.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b86/7397437/5bb62a17cc56/BMRI2020-7909703.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b86/7397437/f322f29e797a/BMRI2020-7909703.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b86/7397437/28a331d53784/BMRI2020-7909703.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b86/7397437/402120446c52/BMRI2020-7909703.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b86/7397437/5ffc0697c252/BMRI2020-7909703.009.jpg

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