Department of Periodontology and Oral Implantology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.
J Periodontol. 2021 Mar;92(3):436-445. doi: 10.1002/JPER.20-0048. Epub 2020 Aug 26.
Peri-implant disease (PID) has not been directly linked to pathological organ changes. The present study assessed the dynamics of serum biochemical parameters in a model of experimental peri-implantitis in dogs, followed by open flap debridement.
Seven male beagle dogs comprised the study group. Procedures were performed as follows-extractions of two premolars and one molar on each mandibular quadrant (Day 0); bone healing time (week14); placement of four rough-surface endoosseous implants, two on each mandibular side; implant uncovering (week 28); induction of experimental peri-implantitis by the use of three ligatures (weeks 31, 34, 37) followed by open flap debridement (week 42). Serum biochemical analysis following each procedure was compared to baseline. Biochemical parameters were assigned into four subsets of variables-inflammation, renal function, liver function, and blood glucose. Wilcoxon paired tests were conducted in order to identify statistically significant differences between baseline data and values obtained after each procedure RESULTS: Following experimental peri-implantitis, the dynamics of renal parameters and blood glucose were minimal whereas statistically significant (P < 0.05) increases were noted for inflammatory (total protein and albumin concentrations) and hepatic (ALT, AST) parameters. A statistically significant (P < 0.05) decrease was only noted for total bilirubin. After open flap debridement, inflammatory (total protein and albumin concentrations) and hepatic (AST) parameters returned to baseline.
Within their limits, the present results indicate that: (a) PID affects inflammatory and hepatic serum biochemical parameters, and (b) following open flap debridement most of the values returned to baseline.
种植体周围疾病（PID）尚未与病理性器官变化直接相关。本研究评估了在犬实验性种植体周围炎模型中血清生化参数的动态变化，随后进行了翻瓣清创术。
本研究纳入了 7 只雄性比格犬。手术程序如下：每个下颌象限拔除两颗前磨牙和一颗磨牙（第 0 天）；骨愈合时间（第 14 周）；在每个下颌侧放置四个粗糙表面的骨内种植体，共四个；种植体暴露（第 28 周）；用三个结扎线诱导实验性种植体周围炎（第 31、34、37 周），然后进行翻瓣清创术（第 42 周）。每次手术后的血清生化分析与基线进行比较。生化参数分为四个变量子集：炎症、肾功能、肝功能和血糖。采用 Wilcoxon 配对检验比较基线数据与每次手术后获得的值。
在实验性种植体周围炎发生后，肾参数和血糖的变化最小，而炎症（总蛋白和白蛋白浓度）和肝（ALT、AST）参数则显著增加（P<0.05）。只有总胆红素明显下降（P<0.05）。翻瓣清创术后，炎症（总蛋白和白蛋白浓度）和肝（AST）参数恢复到基线水平。
在其限制范围内，本研究结果表明：（a）PID 影响炎症和肝血清生化参数；（b）翻瓣清创术后，大多数值恢复到基线水平。
