Grupo de investigación en Enfermedades Tropicales y Resistencia Bacteriana, Universidad del Sinú, Montería, Córdoba, Colombia.
Unidad de ensayos clínicos - PECET, Universidad de Antioquia, Medellín, Colombia.
Int J Infect Dis. 2020 Oct;99:458-465. doi: 10.1016/j.ijid.2020.08.008. Epub 2020 Aug 7.
To determine simultaneous circulation of DENV serotypes and ZIKV in Córdoba, Colombia, during 2015 and 2016.
A total of 294 samples from patients with clinical diagnosis of febrile syndrome compatible with dengue were collected between June 2015 and December 2016. All samples were tested for DENV and ZIKV by RT-PCR using C6/36 cells culture supernatant.
Thirty-three percent of the samples were positive (97/294); from these, 61.8% were positive for DENV and 31% were positive for Zika. The predominant serotype was DENV-2 (70.1%), followed by DENV-3 (8.9%), DENV-4 (6%), and DENV-1 (3%). DENV/ZIKV coinfection was identified in 7.2% of the cases associated with DENV-1 and DENV-3 serotypes. The confirmed cases of dengue, Zika, and DENV/ZIKV coinfections were clinically mild and self-limited.
We reported the co-circulation of all four DENV serotypes, with a higher frequency of DENV-2, and ZIKV introduction in Córdoba department-Colombia in August 2015. This scenario favored the appearance of DENV/ZIKV coinfections.
确定 2015 年至 2016 年期间在哥伦比亚科尔多瓦同时流行的登革热病毒血清型和寨卡病毒。
共采集了 294 份 2015 年 6 月至 2016 年 12 月间临床诊断为发热综合征且符合登革热的患者样本。所有样本均采用 C6/36 细胞培养上清液通过 RT-PCR 法检测登革热病毒和寨卡病毒。
33%的样本呈阳性（97/294）；其中，61.8%为登革热阳性，31%为寨卡阳性。优势血清型为登革热病毒 2 型（70.1%），其次为登革热病毒 3 型（8.9%）、登革热病毒 4 型（6%）和登革热病毒 1 型（3%）。7.2%的病例中发现了登革热病毒/寨卡病毒混合感染，与登革热病毒 1 型和登革热病毒 3 型血清型有关。确诊的登革热、寨卡病毒和登革热病毒/寨卡病毒混合感染病例均为临床轻症且为自限性。
我们报告了在 2015 年 8 月，哥伦比亚科尔多瓦省同时流行的所有四种登革热病毒血清型，其中以登革热病毒 2 型更为常见，同时也出现了寨卡病毒。这种情况有利于出现登革热病毒/寨卡病毒混合感染。
