School of Engineering, Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.
Int J Environ Res Public Health. 2020 Aug 10;17(16):5795. doi: 10.3390/ijerph17165795.
: Inhaled insulin has proven to be viable and, in some aspects, a more effective alternative to subcutaneous insulin. Past and present insulin inhaler devices have not found clinical or commercial success. Insulin inhalers create a dry powder or soft mist insulin aerosol, which does not provide the required uniform particle size or aerosol volume for deep lung deposition. : The primary focus of this review is to investigate the potential treatment of diabetes with a wet insulin aerosol. Vibrating mesh nebulisers allow the passive inhalation of a fine wet mist aerosol for the administration of drugs to the pulmonary system in higher volumes than other small-volume nebulisers. : At present, there is a significant focus on vibrating mesh nebulisers from the pharmaceutical and biomedical industries for the systemic administration of pharmaceuticals for non-traditional applications such as vaccines or the treatment of diabetes. Systemic drug administration using vibrating mesh nebulisers leads to faster-acting pharmaceuticals with a reduction in drug latency. : Systemic conditions such as diabetes, require the innovative development of custom vibrating mesh devices to provide the desired flow rates and droplet size for effective inhaled insulin administration.
吸入胰岛素已被证明是可行的，并且在某些方面，它是一种比皮下胰岛素更有效的替代方法。过去和现在的胰岛素吸入器都没有在临床或商业上取得成功。胰岛素吸入器会产生干粉或软雾胰岛素气溶胶，但无法提供用于深肺沉积所需的均匀颗粒大小或气溶胶体积。
本篇综述的主要重点是研究使用湿胰岛素气雾剂治疗糖尿病的潜力。振动网孔式雾化器允许被动吸入细湿雾气溶胶，以便以比其他小容量雾化器更高的体积将药物施用于肺部系统。
目前，制药和生物医学行业非常关注振动网孔式雾化器，将其用于非传统应用（如疫苗或糖尿病治疗）的药物全身给药。使用振动网孔式雾化器进行全身药物给药可实现更快作用的药物，减少药物潜伏期。
糖尿病等全身疾病需要创新开发定制的振动网孔装置，以提供用于有效吸入胰岛素给药的所需流速和液滴大小。
