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丹麦 COVID-19 封锁期间的早产率。

Danish premature birth rates during the COVID-19 lockdown.

机构信息

Department for Congenital Disorders, Danish National Biobank and Biomarkers, Statens Serum Institut, Copenhagen, Denmark.

Danish Center for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark.

出版信息

Arch Dis Child Fetal Neonatal Ed. 2021 Jan;106(1):93-95. doi: 10.1136/archdischild-2020-319990. Epub 2020 Aug 11.

DOI:10.1136/archdischild-2020-319990
PMID:32788391
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7421710/
Abstract

To explore the impact of COVID-19 lockdown on premature birth rates in Denmark, a nationwide register-based prevalence proportion study was conducted on all 31 180 live singleton infants born in Denmark between 12 March and 14 April during 2015-2020.The distribution of gestational ages (GAs) was significantly different (p=0.004) during the lockdown period compared with the previous 5 years and was driven by a significantly lower rate of extremely premature children during the lockdown compared with the corresponding mean rate for the same dates in the previous years (OR 0.09, 95% CI 0.01 to 0.40, p<0.001). No significant difference between the lockdown and previous years was found for other GA categories.The reasons for this decrease are unclear. However, the lockdown has provided a unique opportunity to examine possible factors related to prematurity. Identification of possible causal mechanisms might stimulate changes in clinical practice.

摘要

为了探究 COVID-19 封锁对丹麦早产儿出生率的影响，对 2015-2020 年间所有在 3 月 12 日至 4 月 14 日期间在丹麦出生的 31180 名单胎活产婴儿进行了一项全国范围基于登记的流行比例研究。在封锁期间，与前 5 年相比，胎龄（GA）的分布显著不同（p=0.004），并且在封锁期间，与前几年同期的相应平均比率相比，极低早产儿的比率显著降低（OR 0.09，95%CI 0.01 至 0.40，p<0.001）。在其他 GA 类别中，封锁期与前几年之间未发现显著差异。造成这种下降的原因尚不清楚。然而，封锁为检查与早产相关的可能因素提供了一个独特的机会。确定可能的因果机制可能会刺激临床实践的改变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/182d/7788224/a80d43123d5e/fetalneonatal-2020-319990f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/182d/7788224/a80d43123d5e/fetalneonatal-2020-319990f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/182d/7788224/a80d43123d5e/fetalneonatal-2020-319990f01.jpg

相似文献

[1]
Danish premature birth rates during the COVID-19 lockdown.

Arch Dis Child Fetal Neonatal Ed. 2020-8-11

[2]
The impact of the COVID-19 lockdown on birthweight among singleton term birth in Denmark.

PLoS One. 2023

[3]
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Eur J Pediatr. 2022-3

[4]
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Am J Obstet Gynecol MFM. 2021-11

[5]
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Eur J Pediatr. 2021-6

[6]
Impact of SARS-CoV-2 on incidence, treatment and outcome of very preterm born infants in Switzerland: a retrospective, population-based cohort study.

Swiss Med Wkly. 2022-5-9

[7]
A decline in planned, but not spontaneous, preterm birth rates in a large Australian tertiary maternity centre during COVID-19 mitigation measures.

Aust N Z J Obstet Gynaecol. 2022-2

[8]
Preterm Singleton Birth Rate during the COVID-19 Lockdown: A Population-Based Study.

Am J Perinatol. 2022-7

[9]
Incidence of New-Onset and Worsening Heart Failure Before and After the COVID-19 Epidemic Lockdown in Denmark: A Nationwide Cohort Study.

Circ Heart Fail. 2020-6-2

[10]
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Acta Paediatr. 2022-9

引用本文的文献

[1]
Seasonal Patterns of Preterm Birth During the COVID-19 Pandemic: A Retrospective Cohort Study in Romania.

Medicina (Kaunas). 2025-8-1

[2]
Impact of COVID-19 Lockdown on the Incidence of Common Pregnancy Complications-Is the Diagnosis of FGR Made Too Generously?

Children (Basel). 2025-8-19

[3]
A systematic review of COVID-19's impact on pregnancy outcomes.

Ann Med Surg (Lond). 2025-4-25

[4]
Impact of Maternal Hyperglycemic and Hypertensive Disorders on Perinatal Outcomes Across the COVID-19 Pandemic.

Womens Health Rep (New Rochelle). 2025-4-28

[5]
Rising public costs of preterm infant hospitalization in South Korea from a nationwide observational study.

Sci Rep. 2025-4-24

[6]
Perinatal Health and Healthcare Utilisation During the COVID-19 Pandemic: A Nationwide Interrupted Time Series Analysis.

Paediatr Perinat Epidemiol. 2025-5

[7]
An international survey on retinopathy of prematurity practice patterns during the COVID-19 pandemic and lessons for future management.

Int Ophthalmol. 2024-10-14

[8]
Is It Possible to Prevent the Thanatogenetic Processes in Premature Babies?

Clin Pract. 2024-9-2

[9]
Characteristics and Rates of Preterm Births During the COVID-19 Pandemic in Germany.

JAMA Netw Open. 2024-9-3

[10]
Explaining the sharp decline in birth rates in Canada and the United States in 2020.

Am J Epidemiol. 2025-4-8

本文引用的文献

[1]
Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study.

Lancet Infect Dis. 2020-3-24

[2]
Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis.

Lancet Glob Health. 2018-10-30

[3]
The global epidemiology of preterm birth.

Best Pract Res Clin Obstet Gynaecol. 2018-4-26

[4]
Physically demanding work, fetal growth and the risk of adverse birth outcomes. The Generation R Study.

Occup Environ Med. 2012-6-27

[5]
Epidemiology and causes of preterm birth.

Lancet. 2008-1-5

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