使用微型纸质设备检测尿液中的电解质

Sensing of electrolytes in urine using a miniaturized paper-based device.

机构信息

Department of Mechanical Engineering, University of Connecticut, Storrs, CT, 06269, USA.

Electrical and Computer Engineering, University of California, Los Angeles, CA, 90095, USA.

出版信息

Sci Rep. 2020 Aug 12;10(1):13620. doi: 10.1038/s41598-020-70456-6.

DOI:10.1038/s41598-020-70456-6

PMID:32788641

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7423618/

Abstract

Analyzing electrolytes in urine, such as sodium, potassium, calcium, chloride, and nitrite, has significant diagnostic value in detecting various conditions, such as kidney disorder, urinary stone disease, urinary tract infection, and cystic fibrosis. Ideally, by regularly monitoring these ions with the convenience of dipsticks and portable tools, such as cellphones, informed decision making is possible to control the consumption of these ions. Here, we report a paper-based sensor for measuring the concentration of sodium, potassium, calcium, chloride, and nitrite in urine, accurately quantified using a smartphone-enabled platform. By testing the device with both Tris buffer and artificial urine containing a wide range of electrolyte concentrations, we demonstrate that the proposed device can be used for detecting potassium, calcium, chloride, and nitrite within the whole physiological range of concentrations, and for binary quantification of sodium concentration.

摘要

分析尿液中的电解质，如钠、钾、钙、氯和亚硝酸盐，对于检测各种疾病具有重要的诊断价值，如肾脏疾病、尿路结石病、尿路感染和囊性纤维化等。理想情况下，通过定期使用尿试纸和便携式工具（如手机）监测这些离子，就可以根据离子浓度来做出明智的决策，以控制这些离子的摄入。在这里，我们报告了一种基于纸张的传感器，可以用于测量尿液中的钠、钾、钙、氯和亚硝酸盐浓度，使用智能手机平台可以准确地进行定量分析。通过使用 Tris 缓冲液和含有广泛电解质浓度的人工尿液对该设备进行测试，我们证明了所提出的设备可用于检测全浓度生理范围内的钾、钙、氯和亚硝酸盐，并且可对钠离子浓度进行二元定量分析。