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High-dose intravenous vitamin C may help in cytokine storm in severe SARS-CoV-2 infection.高剂量静脉注射维生素C可能有助于治疗严重的SARS-CoV-2感染中的细胞因子风暴。
Crit Care. 2020 Aug 13;24(1):500. doi: 10.1186/s13054-020-03228-3.
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Cytokines and COVID-19: friends or foes?细胞因子与 COVID-19：是敌是友？
Hum Vaccin Immunother. 2020 Oct 2;16(10):2363-2365. doi: 10.1080/21645515.2020.1799669. Epub 2020 Aug 25.
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SARS-CoV-2 infection complicated by inflammatory syndrome. Could high-dose human immunoglobulin for intravenous use (IVIG) be beneficial?新型冠状病毒2型感染并发炎症综合征。静脉注射用大剂量人免疫球蛋白（IVIG）是否有益？
Autoimmun Rev. 2020 Jul;19(7):102559. doi: 10.1016/j.autrev.2020.102559. Epub 2020 May 1.
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Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions.在 COVID-19 中，单核细胞和巨噬细胞对局部组织炎症和细胞因子风暴的贡献：来自 SARS 和 MERS 的教训，以及潜在的治疗干预措施。
Life Sci. 2020 Sep 15;257:118102. doi: 10.1016/j.lfs.2020.118102. Epub 2020 Jul 18.
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Aging (Albany NY). 2020 May 2;12(9):7639-7651. doi: 10.18632/aging.103101.
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Hazards of the Cytokine Storm and Cytokine-Targeted Therapy in Patients With COVID-19: Review.新冠病毒肺炎患者细胞因子风暴及细胞因子靶向治疗的危害：综述
J Med Internet Res. 2020 Aug 13;22(8):e20193. doi: 10.2196/20193.
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Sex-biased Immune Responses Following SARS-CoV-2 Infection.感染 SARS-CoV-2 后的性别偏向性免疫反应。
Trends Microbiol. 2020 Dec;28(12):952-954. doi: 10.1016/j.tim.2020.10.002. Epub 2020 Oct 10.
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Cytokine storm induced by SARS-CoV-2.由 SARS-CoV-2 引起的细胞因子风暴。
Clin Chim Acta. 2020 Oct;509:280-287. doi: 10.1016/j.cca.2020.06.017. Epub 2020 Jun 10.

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Assessment of Supplementation with Different Biomolecules in the Prevention and Treatment of COVID-19.评估不同生物分子在 COVID-19 预防和治疗中的补充作用。
Nutrients. 2024 Sep 11;16(18):3070. doi: 10.3390/nu16183070.
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A comprehensive review on pharmacologic agents, immunotherapies and supportive therapeutics for COVID-19.关于COVID-19的药物制剂、免疫疗法和支持性疗法的全面综述。
Narra J. 2022 Dec;2(3):e92. doi: 10.52225/narra.v2i3.92. Epub 2022 Dec 8.
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Vitamin C deficiency in critically ill COVID-19 patients admitted to intensive care unit.入住重症监护病房的危重症 COVID-19 患者的维生素 C 缺乏情况。
Front Med (Lausanne). 2023 Dec 20;10:1301001. doi: 10.3389/fmed.2023.1301001. eCollection 2023.
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Dietary Supplement Use among Iranian Households during COVID-19 Epidemic Lockdown: Less Access in Those Who May Need More National Food and Nutrition Surveillance.新冠疫情封锁期间伊朗家庭的膳食补充剂使用情况：那些可能更需要国家食品和营养监测的人群获取途径较少
Int J Prev Med. 2023 Jul 27;14:99. doi: 10.4103/ijpvm.ijpvm_207_22. eCollection 2023.
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Humulus lupus extract rich in xanthohumol improves the clinical course in critically ill COVID-19 patients.富含黄腐酚的葎草提取物可改善危重症 COVID-19 患者的临床病程。
Biomed Pharmacother. 2023 Feb;158:114082. doi: 10.1016/j.biopha.2022.114082. Epub 2022 Dec 9.
6
Up to 100 g of Intravenous Vitamin C Appears to be Safe and Elicits No Adverse Effects but Needs Further Evaluation in High-Risk Groups.静脉注射高达100克维生素C似乎是安全的，不会引起不良反应，但高危人群需要进一步评估。
Clin Pharmacokinet. 2022 Sep;61(9):1199-1202. doi: 10.1007/s40262-022-01156-9. Epub 2022 Jul 30.
7
COVID-19 epidemic lockdown-induced changes of cereals and animal protein foods consumption of Iran population: the first nationwide survey.COVID-19 疫情封锁导致伊朗人口对谷物和动物蛋白食品消费的变化：首次全国性调查。
J Health Popul Nutr. 2022 Jul 19;41(1):31. doi: 10.1186/s41043-022-00310-0.
8
Vitamin C Plasma Levels Associated with Inflammatory Biomarkers, CRP and RDW: Results from the NHANES 2003-2006 Surveys.维生素 C 血浆水平与炎症生物标志物 CRP 和 RDW 的关系：来自 NHANES 2003-2006 调查的结果。
Nutrients. 2022 Mar 16;14(6):1254. doi: 10.3390/nu14061254.
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Low Levels of Few Micronutrients May Impact COVID-19 Disease Progression: An Observational Study on the First Wave.少数微量营养素水平低可能影响新冠疫情发展：关于第一波疫情的一项观察性研究
Metabolites. 2021 Aug 24;11(9):565. doi: 10.3390/metabo11090565.
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Zinc, Vitamin D and Vitamin C: Perspectives for COVID-19 With a Focus on Physical Tissue Barrier Integrity.锌、维生素D和维生素C：聚焦物理组织屏障完整性的COVID-19研究视角
Front Nutr. 2020 Dec 7;7:606398. doi: 10.3389/fnut.2020.606398. eCollection 2020.

本文引用的文献

1
Two known therapies could be useful as adjuvant therapy in critical patients infected by COVID-19.两种已知疗法可作为新冠病毒感染重症患者的辅助治疗手段。
Rev Esp Anestesiol Reanim (Engl Ed). 2020 May;67(5):245-252. doi: 10.1016/j.redar.2020.03.004. Epub 2020 Apr 14.
2
A new clinical trial to test high-dose vitamin C in patients with COVID-19.一项针对新冠肺炎患者测试高剂量维生素C的新临床试验。
Crit Care. 2020 Apr 7;24(1):133. doi: 10.1186/s13054-020-02851-4.
3
Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes.危重症患者尽管推荐了肠内和肠外摄入，但仍存在维生素 C 缺乏和 Hypovitaminosis C。
Crit Care. 2017 Dec 11;21(1):300. doi: 10.1186/s13054-017-1891-y.
4
Therapeutic efficacy of high-dose vitamin C on acute pancreatitis and its potential mechanisms.高剂量维生素C对急性胰腺炎的治疗效果及其潜在机制
World J Gastroenterol. 2003 Nov;9(11):2565-9. doi: 10.3748/wjg.v9.i11.2565.

High-dose intravenous vitamin C may help in cytokine storm in severe SARS-CoV-2 infection.

作者信息

de Melo Adriana Françozo, Homem-de-Mello Mauricio

机构信息

InSiliTox, Pharmacy Department, Health Sciences School, University of Brasilia, Campus Universitario "Darcy Ribeiro", Brasilia, Brazil.

出版信息

Crit Care. 2020 Aug 13;24(1):500. doi: 10.1186/s13054-020-03228-3.

DOI:10.1186/s13054-020-03228-3
PMID:32792018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7424130/
Abstract
摘要