Tam Shing Yau, Tam Victor C W, Ramkumar Shanmugasundaram, Khaw May Ling, Law Helen K W, Lee Shara W Y
Department of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Department of Clinical Oncology, NHS Foundation Trust, University Hospital Southampton, Southampton, United Kingdom.
Front Oncol. 2020 Jul 24;10:1255. doi: 10.3389/fonc.2020.01255. eCollection 2020.
Photobiomodulation (PBM) using low-level laser therapy (LLLT) is a treatment that is increasingly used in oncology. Studies reported enhancement of wound healing with reduction in pain, tissue swelling and inflammatory conditions such as radiation dermatitis, oral mucositis, and lymphedema. However, factors such as wavelength, energy density and irradiation frequency influence the cellular mechanisms of LLLT. Moreover, the effects of LLLT vary according to cell types. Thus, controversy arose as a result of poor clinical response reported in some studies that may have used inadequately planned treatment protocols. Since LLLT may enhance tumor cell proliferation, these will also need to be considered before clinical use. This review aims to summarize the current knowledge of the cellular mechanisms of LLLT by considering its effects on cell proliferation, metabolism, angiogenesis, apoptosis and inflammation. With a better understanding of the cellular mechanisms, bridging findings from laboratory studies to clinical application can be improved.
使用低强度激光疗法（LLLT）的光生物调节（PBM）是一种在肿瘤学中越来越常用的治疗方法。研究报告称，这种疗法可促进伤口愈合，减轻疼痛、组织肿胀以及诸如放射性皮炎、口腔黏膜炎和淋巴水肿等炎症状况。然而，波长、能量密度和照射频率等因素会影响LLLT的细胞机制。此外，LLLT的效果因细胞类型而异。因此，一些研究报告的临床反应不佳引发了争议，这些研究可能使用了规划不当的治疗方案。由于LLLT可能会增强肿瘤细胞增殖，因此在临床应用前也需要考虑这些因素。本综述旨在通过考虑LLLT对细胞增殖、代谢、血管生成、凋亡和炎症的影响，总结当前对其细胞机制的认识。更好地理解细胞机制有助于改善从实验室研究到临床应用的转化。
