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低水平激光疗法在骨愈合中的作用：系统评价。

The Role of Low-Level Laser Therapy in Bone Healing: Systematic Review.

机构信息

Orthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy.

Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.

出版信息

Int J Mol Sci. 2023 Apr 12;24(8):7094. doi: 10.3390/ijms24087094.

DOI:10.3390/ijms24087094
PMID:37108257
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10139216/
Abstract

Low-level laser therapy (LLLT) is a treatment that is increasingly used in orthopedics practices. In vivo and in vitro studies have shown that low-level laser therapy (LLLT) promotes angiogenesis, fracture healing and osteogenic differentiation of stem cells. However, the underlying mechanisms during bone formation remain largely unknown. Factors such as wavelength, energy density, irradiation and frequency of LLLT can influence the cellular mechanisms. Moreover, the effects of LLLT are different according to cell types treated. This review aims to summarize the current knowledge of the molecular pathways activated by LLLT and its effects on the bone healing process. A better understanding of the cellular mechanisms activated by LLLT can improve its clinical application.

摘要

低水平激光疗法（LLLT）是一种在骨科实践中越来越常用的治疗方法。体内和体外研究表明，低水平激光疗法（LLLT）可促进血管生成、骨折愈合和干细胞的成骨分化。然而，骨形成过程中的潜在机制在很大程度上仍然未知。诸如波长、能量密度、辐照和 LLLT 的频率等因素会影响细胞机制。此外，LLLT 的效果因所处理的细胞类型而异。本文综述了 LLLT 激活的分子途径及其对骨愈合过程的影响的现有知识。更好地了解 LLLT 激活的细胞机制可以改善其临床应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba9/10139216/c9de76f5694f/ijms-24-07094-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba9/10139216/3d3070054041/ijms-24-07094-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba9/10139216/c9de76f5694f/ijms-24-07094-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba9/10139216/3d3070054041/ijms-24-07094-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba9/10139216/c9de76f5694f/ijms-24-07094-g002.jpg

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引用本文的文献

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J Lasers Med Sci. 2025-6-29

[2]
Clinical, radiographic and molecular efficacy of LLLT along with minimally invasive flaps in regeneration of periodontal intrabony defects: a randomized controlled clinical trial.

Clin Oral Investig. 2025-8-12

[3]
Influence of Low-Level Red Laser Irradiation on the Proliferation, Viability, and Differentiation of Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells.

Life (Basel). 2025-7-17

[4]
Boosting osteoblast differentiation: enhancing the effects of low-level blue laser therapy on human embryonic stem cell-derived mesenchymal stem cells to improve viability and calcium deposition.

Lasers Med Sci. 2025-7-22

[5]
Assessment of photobiomodulation effect on osteoblast-like MG-63 cell biological behavior: analyzing proliferation and migration in the absence or presence of nicotine.

BMC Oral Health. 2025-7-3

[6]
Low-level laser therapy enhances osteogenic differentiation of gingiva-derived stem cells in 2D and 3D cultures.

Sci Rep. 2025-7-2

[7]
Sequential Triple Therapy for Facial Inflammation: Prospective Evaluation of Facial Microneedle, Hydrolifting, and Intense Pulsed Light Therapy.

J Cosmet Dermatol. 2025-7

[8]
Molecular mechanisms of deer antler in promoting osteogenic differentiation of human mesenchymal stem cells via JUN modulation.

Front Immunol. 2025-5-29

[9]
Gingival Stem Cell-Conditioned Media and Low-Level Laser Therapy Enhance Periodontal Ligament Stem Cells Function by Upregulating Wnt and TGF-β Pathway Components: An In Vitro Study.

Clin Exp Dent Res. 2025-6

[10]
Efficacy of Three-Dimensional Bioactive Composites in Long Bone Repair with Photobiomodulation.

Materials (Basel). 2025-4-9

本文引用的文献

[1]
A Novel Concept of Combined High-Level-Laser Treatment and Transcutaneous Photobiomodulation Therapy Utilisation in Orthodontic Periodontal Interface Management.

Sensors (Basel). 2022-3-15

[2]
High-frequency near-infrared diode laser irradiation suppresses IL-1β-induced inflammatory cytokine expression and NF-κB signaling pathways in human primary chondrocytes.

Lasers Med Sci. 2022-3

[3]
Low level laser therapy promotes bone regeneration by coupling angiogenesis and osteogenesis.

Stem Cell Res Ther. 2021-8-3

[4]
Pulsed Electromagnetic Fields in Bone Healing: Molecular Pathways and Clinical Applications.

Int J Mol Sci. 2021-7-9

[5]
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.

BMJ. 2021-3-29

[6]
A Review of Recent Developments in the Molecular Mechanisms of Bone Healing.

Int J Mol Sci. 2021-1-14

[7]
Laser and LED photobiomodulation effects in osteogenic or regular medium on rat calvaria osteoblasts obtained by newly forming bone technique.

Lasers Med Sci. 2021-4

[8]
Low-level laser therapy (LLLT) in sites grafted with osteoconductive bone substitutes improves osseointegration.

Lasers Med Sci. 2020-9

[9]
Evaluation of photobiomodulation effects on pain, edema, paresthesia, and bone regeneration after surgically assisted rapid maxillary expansion: Study protocol for a randomized, controlled, and double blind clinical trial.

Medicine (Baltimore). 2019-11

[10]
Low-level laser therapy induces human umbilical vascular endothelial cell proliferation, migration and tube formation through activating the PI3K/Akt signaling pathway.

Microvasc Res. 2019-11-14

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