严重障碍量表在台湾中重度阿尔茨海默病患者中的信度和效度。

Reliability and validity of the severe impairment battery in Taiwanese patients with moderate to severe Alzheimer's disease.

机构信息

Department of Psychiatry, Division of Geriatric Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Dementia Center, Department of Neurology, Taipei Neuroscience Institute, Shuang Ho Hospital, College of Medicine, Taipei Medical University, New Taipei City, Taiwan, ROC.

出版信息

J Chin Med Assoc. 2020 Nov;83(11):1014-1019. doi: 10.1097/JCMA.0000000000000412.

DOI:10.1097/JCMA.0000000000000412

PMID:32796320

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7647445/

Abstract

BACKGROUND

The severe impairment battery (SIB) was developed to evaluate cognitive functions in moderate to severe dementia patients. We aimed to examine the reliability and validity of the Taiwanese version of the SIB (T-SIB) in patients with moderate to severe Alzheimer's disease (AD).

METHODS

AD patients with clinical dementia rating (CDR) stage 2 (n = 79) or 3 (n = 21) and scores <15 on the Taiwanese version of mini mental state examination (T-MMSE) were recruited from six hospitals in Taiwan. Cronbach's alpha was used to evaluate the internal consistency of the T-SIB. The CDR and functional assessment staging (FAST) scores were used to assess dementia severity.

RESULTS

We recruited 100 AD patients (73 women and 27 men; mean T-SIB score, 56.4 ± 24.8). The mean T-SIB total score for patients with CDR 2 and 3 were 60.3 ± 23.3 and 41.2 ± 24.9, respectively. The internal consistency of the T-SIB was 0.96. The T-SIB was moderately correlated with the T-MMSE (Pearson's correlation coefficient = 0.76). The areas under the curve for discriminating between CDR 2 and CDR 3 were 0.81 (95% CI = 0.91-0.71) and 0.72 (95% CI = 0.84-0.61), respectively. Using a cut-off score of 59, the T-SIB had a sensitivity of 80% and specificity of 61% for discriminating between CDR 2 and CDR 3. Using a cut-off score of 45, the T-SIB had a sensitivity of 83.3% and specificity of 73.1% for discriminating between the FAST stage 7c.

CONCLUSION

T-SIB is a reliable and valid instrument for measuring cognition of severely demented Taiwanese AD patients.

摘要

背景

严重损伤电池（SIB）旨在评估中度至重度痴呆患者的认知功能。我们旨在研究台湾版 SIB（T-SIB）在中度至重度阿尔茨海默病（AD）患者中的可靠性和有效性。

方法

从台湾六家医院招募临床痴呆评定量表（CDR）阶段 2（n=79）或 3（n=21）且台湾版简易精神状态检查表（T-MMSE）得分<15 的 AD 患者。采用克朗巴赫α评估 T-SIB 的内部一致性。CDR 和功能评估分期（FAST）评分用于评估痴呆严重程度。

结果

我们共招募了 100 名 AD 患者（73 名女性和 27 名男性；T-SIB 平均得分 56.4±24.8）。CDR 2 和 3 患者的 T-SIB 总分分别为 60.3±23.3 和 41.2±24.9。T-SIB 的内部一致性为 0.96。T-SIB 与 T-MMSE 中度相关（皮尔逊相关系数=0.76）。区分 CDR 2 和 CDR 3 的曲线下面积分别为 0.81（95%CI=0.91-0.71）和 0.72（95%CI=0.84-0.61）。使用 59 分的截断值，T-SIB 区分 CDR 2 和 CDR 3 的敏感性为 80%，特异性为 61%。使用 45 分的截断值，T-SIB 区分 FAST 阶段 7c 的敏感性为 83.3%，特异性为 73.1%。