Badv Maryam, Bayat Fereshteh, Weitz Jeffrey I, Didar Tohid F
School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada; Department of Mechanical Engineering, McMaster University, Hamilton, Ontario, Canada.
School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada.
Biomaterials. 2020 Nov;258:120291. doi: 10.1016/j.biomaterials.2020.120291. Epub 2020 Aug 7.
Device-associated clot formation and poor tissue integration are ongoing problems with permanent and temporary implantable medical devices. These complications lead to increased rates of mortality and morbidity and impose a burden on healthcare systems. In this review, we outline the current approaches for developing single and multi-functional surface coating techniques that aim to circumvent the limitations associated with existing blood-contacting medical devices. We focus on surface coatings that possess dual hemocompatibility and biofunctionality features and discuss their advantages and shortcomings to providing a biocompatible and biodynamic interface between the medical implant and blood. Lastly, we outline the newly developed surface modification techniques that use lubricant-infused coatings and discuss their unique potential and limitations in mitigating medical device-associated complications.
与设备相关的血栓形成和组织整合不良是永久性和临时性植入式医疗设备一直存在的问题。这些并发症导致死亡率和发病率上升，并给医疗系统带来负担。在本综述中，我们概述了目前开发单功能和多功能表面涂层技术的方法，这些技术旨在克服与现有血液接触医疗设备相关的局限性。我们重点关注具有双重血液相容性和生物功能性的表面涂层，并讨论它们在提供医疗植入物与血液之间的生物相容性和生物动力学界面方面的优缺点。最后，我们概述了新开发的使用注入润滑剂涂层的表面改性技术，并讨论它们在减轻与医疗设备相关并发症方面的独特潜力和局限性。
