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柑橘属果皮精油诱发的IV型超敏反应。

Peel Essential Oil-Induced Type IV Hypersensitivity Reaction.

作者信息

Mahdani Fatma Yasmin, Parmadiati Adiastuti Endah, Ernawati Diah Savitri, Husain Hasrul, Ekaperdana Sekar Alifa Putri, Rachmaningayu Ulyasari, Hadi Priyo, Hendarti Hening Tuti, Surboyo Meircurius Dwi Condro

机构信息

Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya 60132, Indonesia.

Oral Medicine Specialist Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya 60132, Indonesia.

出版信息

J Exp Pharmacol. 2020 Jul 27;12:213-220. doi: 10.2147/JEP.S256139. eCollection 2020.

DOI:10.2147/JEP.S256139
PMID:32801948
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7394596/
Abstract

BACKGROUND

Several studies have shown anti-inflammatory, anti-microbial, antifungal, and antioxidant effects from -peel essential oil (Cl-PEO). Cl-PEO can be developed as topical drugs for oral ulceration because of its potential active components. There have been no studies on the topical application of Cl-PEO inducing type IV hypersensitivity reaction.

PURPOSE

To investigate the potential of Cl-PEO from Batu City to induce type IV hypersensitivity reactions based on clinical changes, lymphocytes, macrophages, IFNγ, andIL10 expression.

METHODS

This study was adapted from a guinea pig maximization-test method in Indonesia and the guidance of ISO 10,993-10:2010, and conducted on 20 guinea pigs () divided into a control group and a treatment group. The treatment group was given Cl-PEO and the control group CMC-Na. Clinical changes were observed, then tissue specimens taken for hematoxylin-eosin and immunohistochemistry staining.

RESULTS

There were no clinical changes after exposure. Lymphocyte and macrophage numbers and IFNγ and IL10 expression increased in the treatment group compared to the control group (=0).

CONCLUSION

Cl-PEO can induce type IV hypersensitivity reactions in guinea pigs based on cellular and molecular cytokines, but there are no clinical changes after topical application.

摘要

背景

多项研究表明，-果皮精油（Cl-PEO）具有抗炎、抗菌、抗真菌和抗氧化作用。由于其潜在的活性成分，Cl-PEO可开发为治疗口腔溃疡的局部用药。目前尚无关于Cl-PEO局部应用诱导IV型超敏反应的研究。

目的

基于临床变化、淋巴细胞、巨噬细胞、IFNγ和IL10表达，研究峇都市的Cl-PEO诱导IV型超敏反应的潜力。

方法

本研究采用印度尼西亚豚鼠最大化试验方法并遵循ISO 10,993-10:2010的指导，对20只豚鼠（）进行实验，分为对照组和治疗组。治疗组给予Cl-PEO，对照组给予羧甲基纤维素钠（CMC-Na）。观察临床变化，然后采集组织标本进行苏木精-伊红染色和免疫组织化学染色。

结果

暴露后无临床变化。与对照组相比，治疗组的淋巴细胞和巨噬细胞数量以及IFNγ和IL10表达增加（=0）。

结论

基于细胞和分子细胞因子，Cl-PEO可在豚鼠中诱导IV型超敏反应，但局部应用后无临床变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420f/7394596/1f71f7f12439/JEP-12-213-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420f/7394596/28fed753e27f/JEP-12-213-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420f/7394596/b5e01877e395/JEP-12-213-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420f/7394596/158081bbe203/JEP-12-213-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420f/7394596/07d3508d301e/JEP-12-213-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420f/7394596/1f71f7f12439/JEP-12-213-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420f/7394596/28fed753e27f/JEP-12-213-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420f/7394596/b5e01877e395/JEP-12-213-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420f/7394596/158081bbe203/JEP-12-213-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420f/7394596/07d3508d301e/JEP-12-213-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/420f/7394596/1f71f7f12439/JEP-12-213-g0006.jpg

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