评估儿童腺病毒肺炎加重的危险因素。
Evaluation of Risk Factors for Exacerbations in Children with Adenoviral Pneumonia.
机构信息
Department of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
Biomed Res Int. 2020 Jul 31;2020:4878635. doi: 10.1155/2020/4878635. eCollection 2020.
PURPOSE
The aim of this work was to analyze clinical features and laboratory findings of children with adenovirus pneumonia and guide clinical diagnosis, treatment, and assessment of disease severity. . Retrospective analysis of clinical data of 285 children with adenoviral pneumonia who were hospitalized in Wuhan Children's Hospital from December 2018 to October 2019. According to the assessment criteria for severe pneumonia, it was divided into the severe group (92 cases) and the nonsevere group (193 cases). Collected clinical manifestations, complications, and laboratory test indicators in two groups of children and conducted all statistical analyses.
RESULTS
The risk of fever and wheezing was significantly higher in the severe group than in the nonsevere group. The difference was statistically significant ( < 0.05). The risk of complications in the severe group was significantly higher than that in the nonsevere group. The difference was statistically significant ( < 0.05). The levels of AST, LDH-L, PCT, ferritin, and D-dimer in the severe group were significantly higher than those in the nonsevere group. The difference was statistically significant ( < 0.05).
CONCLUSION
Children with severe adenovirus pneumonia have severe clinical manifestations and many complications. AST, LDH-L, PCT, ferritin, and D-dimer levels have important clinical implications for assessing disease severity.
目的
本研究旨在分析儿童腺病毒肺炎的临床特征和实验室检查结果，以指导临床诊断、治疗和疾病严重程度评估。方法：回顾性分析 2018 年 12 月至 2019 年 10 月在武汉儿童医院住院的 285 例腺病毒肺炎患儿的临床资料。根据重症肺炎评估标准，分为重症组（92 例）和非重症组（193 例）。收集两组患儿的临床表现、并发症及实验室检查指标，并进行统计学分析。结果：重症组发热、喘息发生率高于非重症组，差异有统计学意义（ < 0.05）。重症组并发症发生率高于非重症组，差异有统计学意义（ < 0.05）。重症组 AST、LDH-L、PCT、铁蛋白、D-二聚体水平均高于非重症组，差异有统计学意义（ < 0.05）。结论：儿童重症腺病毒肺炎临床表现重，并发症多，AST、LDH-L、PCT、铁蛋白、D-二聚体水平对评估疾病严重程度有重要的临床意义。
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