Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218; Center for Cell Dynamics, Johns Hopkins University, Baltimore, MD 21218; Institute for NanoBio Technology, Johns Hopkins University, Baltimore, MD 21218.
Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218; Center for Cell Dynamics, Johns Hopkins University, Baltimore, MD 21218; Department of Mechanical Engineering, Institute for NanoBio Technology, Johns Hopkins University, Baltimore, MD 21218.
J Biomech Eng. 2020 Oct 1;142(10). doi: 10.1115/1.4048110.
Cells sense biophysical cues in the micro-environment and respond to the cues biochemically and biophysically. Proper responses from cells are critical to maintain the homeostasis in the body. Abnormal biophysical cues will cause pathological development in the cells; pathological or aging cells, on the other hand, can alter their micro-environment to become abnormal. In this minireview, we discuss four important biophysical cues of the micro-environment-stiffness, curvature, extracellular matrix (ECM) architecture and viscosity-in terms of their roles in health, aging, and diseases.
细胞感知微环境中的生物物理线索，并在生物化学和生物物理上对这些线索做出反应。细胞的适当反应对于维持体内的动态平衡至关重要。异常的生物物理线索会导致细胞发生病理性发育；另一方面，病理性或衰老的细胞可以改变其微环境，使其变得异常。在这篇综述中，我们讨论了微环境中的四个重要生物物理线索——硬度、曲率、细胞外基质 (ECM) 结构和粘度——及其在健康、衰老和疾病中的作用。
