Department of Biomaterials, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.
Medical Microbiology and Immunology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Clin Oral Investig. 2021 Apr;25(4):1879-1888. doi: 10.1007/s00784-020-03493-0. Epub 2020 Aug 15.
This study was designed to investigate the antimicrobial properties, compressive strength and fluoride release capacities of high-viscous glass ionomer cements (GICs) after incorporation of cinnamon and thyme essential oils.
Experimental-modified GICs were prepared by incorporation of thyme and cinnamon essential oils into the liquid phase of the cement at 5 and 10% v/v. Antimicrobial activity against selected microorganisms (Streptococcus mutans and Candida albicans) was done using direct contact test. Compressive strength of the four new formulations and control group was tested using a universal testing machine while fluoride ion release was measured by ion-selective electrode at 1, 7, 14 and 28 days. Data analysis and comparisons between groups were performed using factorial and one-way ANOVA and Tukey's tests.
All newly formulated GICs exhibited significantly higher inhibitory effects against both Streptococcus mutans and Candida albicans growth when compared to conventional GIC (p < 0.05). Compressive strength of 5% cinnamon-modified GIC (MPa = 160.32 ± 6.66) showed no significant difference when compared with conventional GIC (MPa = 165.7 ± 5.769) (p value > 0.05). Cumulative fluoride-releasing pattern at days 7, 14, and 28 were 10% cinnamon-GIC > 5% thyme-GIC > 5% cinnamon-GIC > 10% thyme GIC > conventional GIC.
Incorporation of 5% cinnamon oil into glass ionomer resulted in better antimicrobial effects against S. mutans and C. albicans and increased fluoride-release capacity without jeopardizing its compressive strength.
The 5% cinnamon-modified GIC appears to be a promising alternative restorative material in ART technique.
本研究旨在探讨肉桂和百里香精油掺入高粘性玻璃离子水门汀（GIC）后其抗菌性能、抗压强度和氟释放能力。
通过将百里香和肉桂精油分别以 5%和 10%的体积比掺入水门汀的液相中制备实验改性 GIC。采用直接接触试验检测对选定微生物（变形链球菌和白色念珠菌）的抗菌活性。使用万能试验机测试四种新配方和对照组的抗压强度，同时在第 1、7、14 和 28 天使用离子选择电极测量氟离子释放量。使用析因和单向方差分析及 Tukey 检验对数据进行分析和组间比较。
与传统 GIC 相比，所有新配方的 GIC 均显著抑制变形链球菌和白色念珠菌的生长（p<0.05）。与传统 GIC（MPa=165.7±5.769）相比，5%肉桂改性 GIC（MPa=160.32±6.66）的抗压强度无显著差异（p 值>0.05）。7、14 和 28 天时的累积氟释放模式为 10%肉桂-GIC>5%百里香-GIC>5%肉桂-GIC>10%百里香 GIC>传统 GIC。
将 5%肉桂油掺入玻璃离子体可提高对 S. mutans 和 C. albicans 的抗菌效果并增加氟释放能力，同时不影响其抗压强度。
5%肉桂改性 GIC 似乎是 ART 技术中一种有前途的替代修复材料。
