Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Alameda Dr Octávio Pinheiro Brisolla, 9-75, Bauru, 17012-901, Brazil.
Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo (HRAC/USP), Silvio Marchione, 3-20, Bauru, 17012-900, Brazil.
Clin Oral Investig. 2021 Apr;25(4):2081-2092. doi: 10.1007/s00784-020-03518-8. Epub 2020 Aug 15.
To evaluate the impact of oral alterations on the quality of life (QoL) of individuals with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
A case-control study in 32 individuals with RA, 28 with SLE, and 29 in the control group (CG). The questionnaire SF-36 (Medical Outcomes Study Short-Form 36) was used to evaluate the health-related quality of life (HRQoL), and OHIP-14 (Oral Health Impact Profile-14) was used to evaluate the oral health-related quality of life (OHRQoL). The severity of xerostomia was evaluated by the Xerostomia Inventory (XI). In the clinical examination, decayed (D-T), missing(M-T), and filled teeth (F-T) (DMF-T), periodontal status, plaque index (PI), gingival index (GI), unstimulated whole salivary flow rate (UWSFR), and stimulated whole salivary flow rate (SWSFR) were also assessed. Data were analyzed by Student's t tests, chi-square test, Kruskal-Wallis test, ANOVA, Pearson's correlation, and Spearman's correlation.
Individuals with RA had a higher caries index (D-T/p = 0.004) and more frequent periodontal disease (PI/p = 0.017). In the SLE group, there was a significant lower salivary flow (SFR/p = 0.016, SFMS/p = 0.004) and severe xerostomia (p = 0.002). The impact of ORHQoL in individuals with RA occurred due to oral candidiasis, halitosis, and xerostomia, compromising the HRQoL. Overall, OHRQoL and HRQoL were more compromised in individuals with SLE, with xerostomia being the main oral problem.
Individuals with RA and SLE present oral diseases with negative impact on their QoL.
This study shows the main oral manifestations in rheumatic autoimmune diseases, with mainly xerostomia compromising the quality of life.
评估口腔改变对类风湿关节炎（RA）和系统性红斑狼疮（SLE）患者生活质量（QoL）的影响。
这是一项 32 例 RA 患者、28 例 SLE 患者和 29 例对照组（CG）的病例对照研究。使用健康相关生活质量量表（SF-36）评估健康相关生活质量（HRQoL），使用口腔健康影响量表（OHIP-14）评估口腔健康相关生活质量（OHRQoL）。使用口干症量表（XI）评估口干症严重程度。在临床检查中，还评估了龋齿（D-T）、缺失（M-T）和填充牙（F-T）（DMF-T）、牙周状况、菌斑指数（PI）、牙龈指数（GI）、非刺激性全唾液流率（UWSFR）和刺激性全唾液流率（SWSFR）。采用学生 t 检验、卡方检验、Kruskal-Wallis 检验、方差分析、Pearson 相关和 Spearman 相关进行数据分析。
RA 患者的龋齿指数（D-T/p = 0.004）更高，牙周病更常见（PI/p = 0.017）。SLE 组的唾液流率明显较低（SFR/p = 0.016，SFMS/p = 0.004），且口干症严重（p = 0.002）。RA 患者的 ORHQoL 受口腔念珠菌病、口臭和口干的影响，从而影响 HRQoL。总体而言，SLE 患者的 OHRQoL 和 HRQoL 受损更严重，口干症是主要的口腔问题。
RA 和 SLE 患者存在口腔疾病，对其生活质量有负面影响。
本研究显示了风湿性自身免疫性疾病的主要口腔表现，主要是口干症影响生活质量。
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