Depierreux M, Goldman M, Fayt I, Richard C, Quintin J, Dhaene M, Van Herweghem J L
Cliniques Universitaires de Bruxelles, Hôpital Erasme, Université Libre de Bruxelles, Belgium.
J Clin Pathol. 1988 Feb;41(2):158-62. doi: 10.1136/jcp.41.2.158.
Osteoarticular amyloidosis occurred in a patient receiving long term haemodialysis. Histological examination showed that the amyloid deposit was surrounded by inflammatory cells and macrophages filled with haemosiderin. Electron microscopy showed that the amyloid fibrils were in close contact with cytoplasmic expansions, or located in intracytoplasmic pockets of the infiltrating cells. Immunohistological and immunoultrastructural observations confirmed that beta 2-microglobulin was a major constituent of amyloidosis associated with dialysis. Amyloid P component was also detected within the amyloid deposits. These findings suggest that amyloid P component, iron overload, or macrophage derived factors could have a role in the polymerisation of beta 2-microglobulin into amyloid deposit.
骨关节淀粉样变性发生在一名长期接受血液透析的患者身上。组织学检查显示淀粉样沉积物被炎性细胞和充满含铁血黄素的巨噬细胞包围。电子显微镜检查显示淀粉样纤维与细胞质扩张紧密接触,或位于浸润细胞的胞质内小囊泡中。免疫组织学和免疫超微结构观察证实β2-微球蛋白是与透析相关的淀粉样变性的主要成分。在淀粉样沉积物中也检测到了淀粉样P成分。这些发现表明淀粉样P成分、铁过载或巨噬细胞衍生因子可能在β2-微球蛋白聚合成淀粉样沉积物的过程中起作用。