Chemistry Department, Faculty of Science, Cairo University, Gamaa Street, Giza 12613, Egypt.
Chemistry Department, Faculty of Science, Cairo University, Gamaa Street, Giza 12613, Egypt.
Mater Sci Eng C Mater Biol Appl. 2020 Nov;116:111110. doi: 10.1016/j.msec.2020.111110. Epub 2020 Jun 5.
Ivabradine hydrochloride (IVB) has shown high medical importance as it is a medication for lowering the heart rate for the symptomatic chronic heart failure and symptomatic management of stable angina pectoralis. The high dose of IVB may cause severe and prolonged bradycardia, uncontrolled blood pressure, headache, and blurred vision. In this study, a highly sensitive carbon-paste electrode (CPEs) was constructed for the potentiometric determination of IVB in pharmaceutical formulations. t-Butyl calixarene (t-BCX) was used as an ionophore due to its ability to mask IVB in the cavity via multiple H-bonding at the lower rim, as estimated quantitatively by the sandwich membrane method (Log β = 8.62). Besides, the use of multi-walled carbon nanotubes decorated with FeO nanoparticles (FeO@MWCNTs) as an additive for the paste electrode significantly improved the detection limit of the sensor up to 36 nM, with Nernstian response of 58.9 mV decade in the IVB linear dynamic range of 10-10 M in aqueous solutions. The constructed sensors showed high selectivity against interfering species that may exist in physiological fluids or pharmaceutical formulations (e.g. Na, K, NH, Ca, Mg, Ba, Fe, Co, Cr, Sr, glucose, lactose, maltose, glycine, dopamine, and ascorbic acid). The sensors were successfully employed for IVB determination in the pharmaceutical formulations (Savapran®).
盐酸伊伐布雷定 (IVB) 具有重要的医学意义，因为它是一种用于降低心率的药物，适用于有症状的慢性心力衰竭和稳定型心绞痛的症状管理。高剂量的 IVB 可能导致严重且持久的心动过缓、不受控制的血压、头痛和视力模糊。在这项研究中，构建了一种高灵敏度的碳糊电极 (CPEs)，用于测定药物制剂中的 IVB。叔丁基杯[4]芳烃 (t-BCX) 被用作离子载体，因为它能够通过在较低边缘处形成多个氢键来掩蔽 IVB，这可以通过夹心膜法进行定量估计 (Log β= 8.62)。此外，使用 FeO 纳米粒子修饰的多壁碳纳米管 (FeO@MWCNTs) 作为糊电极的添加剂，可将传感器的检测限显著提高至 36 nM，在水溶液中 IVB 的线性动态范围为 10-10 M 时，响应为 58.9 mV 每 decade。所构建的传感器对可能存在于生理流体或药物制剂中的干扰物质具有高选择性（例如 Na、K、NH、Ca、Mg、Ba、Fe、Co、Cr、Sr、葡萄糖、乳糖、麦芽糖、甘氨酸、多巴胺和抗坏血酸）。该传感器成功地用于测定药物制剂中的 IVB（Savapran®）。
