Pacini G, Valerio A, Beccaro F, Nosadini R, Cobelli C, Crepaldi G
Department of Internal Medicine, University of Padua, Italy.
J Am Geriatr Soc. 1988 Apr;36(4):317-23. doi: 10.1111/j.1532-5415.1988.tb02358.x.
Glucose intolerance has been observed often in elderly subjects, but it is not yet clear whether this impaired metabolic state is due to the aging process itself or is secondary to the appearance of other age-related variables. This study attempts to elucidate the effect of age in itself on factors controlling glucose tolerance. Several metabolic parameters were measured in 10 young male controls (23-29 yr) and 17 nonhospitalized, healthy, nonobese, old (60-80 yr) male subjects. Insulin binding to circulating cells was performed along with the intravenous glucose tolerance test, and the data were analyzed by the minimal model method. This approach yields the following measures: tissue insulin sensitivity (SI), fractional glucose disappearance at basal insulin (glucose effectiveness, SG), and first (phi 1) and second (phi 2) phase beta-cell responsiveness to glucose. Insulin-binding capacity to monocytes and erythrocytes was respectively 6.03% +/- 0.57% and 5.96% +/- 0.53% (elderly), 5.97% +/- 0.39% and 5.36% +/- 0.57% (young); SI was 6.20 +/- 0.59 X 10(4) min-1/(microU/mL) (elderly) and 6.35 +/- 0.30 (young); SG was 0.016 +/- 0.002 min-1 (elderly) and 0.019 +/- 0.003 (young); phi 1 was 1.84 +/- 0.29 min-1 (microU/mL)/(mg/dL) (elderly) and 3.37 +/- 0.84 (young); phi 2 was 13.80 +/- 1.78 X 10(4) min-2 (microU/mL)/(mg/dL) (elderly) and 9.59 +/- 2.65 (young). These results show no change with aging of tissue insulin sensitivity and an intact beta-cell activity, suggesting that age per se does not contribute to the deterioration of glucose tolerance when the effect of other age-related variables, eg, obesity and physical inactivity, is precluded.
在老年受试者中经常观察到葡萄糖耐量异常，但目前尚不清楚这种代谢状态受损是由于衰老过程本身，还是继发于其他与年龄相关的变量的出现。本研究试图阐明年龄本身对控制葡萄糖耐量的因素的影响。对10名年轻男性对照者（23 - 29岁）和17名未住院、健康、非肥胖的老年男性受试者（60 - 80岁）测量了几个代谢参数。在进行静脉葡萄糖耐量试验的同时测定胰岛素与循环细胞的结合情况，并采用最小模型法对数据进行分析。这种方法得出以下指标：组织胰岛素敏感性（SI）、基础胰岛素水平下的葡萄糖分数消失率（葡萄糖效能，SG）以及第一（phi 1）和第二（phi 2）阶段β细胞对葡萄糖的反应性。老年组单核细胞和红细胞的胰岛素结合能力分别为6.03%±0.57%和5.96%±0.53%，年轻组分别为5.97%±0.39%和5.36%±0.57%；SI老年组为6.20±0.59×10⁴ min⁻¹/(μU/mL)，年轻组为6.35±0.30；SG老年组为0.016±0.002 min⁻¹，年轻组为0.019±0.003；phi 1老年组为1.84±0.29 min⁻¹(μU/mL)/(mg/dL)，年轻组为3.37±0.84；phi 2老年组为13.80±1.78×10⁴ min⁻²(μU/mL)/(mg/dL)，年轻组为9.59±2.65。这些结果表明，组织胰岛素敏感性不会随年龄增长而变化，β细胞活性保持完好，这表明在排除其他与年龄相关的变量（如肥胖和缺乏身体活动）的影响时，年龄本身并不会导致葡萄糖耐量恶化。
