Hu Junfei, Yang Lei, Yang Peng, Jiang Shaohua, Liu Xianhu, Li Yiwen
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
Biomater Sci. 2020 Sep 21;8(18):4940-4950. doi: 10.1039/d0bm01070g. Epub 2020 Aug 18.
Polydopamine (PDA) is the most typical kind of synthetic melanin, which possesses interesting properties such as antioxidation, photoprotection, metal chelation, and energy dissipation. Over the past few years, PDA has been successfully synthesized via polymerization methods and has demonstrated excellent free radical scavenging ability. The related applications have been rapidly expanded to include sunscreens, anti-inflammatory treatment, and composite material fabrication. Despite great progress, the comprehensive mechanisms of its free radical scavenging behaviors are not fully understood. This article strives to summarize the possible mechanisms, established antioxidant regulation methods and the related biomedical applications of PDA free radical scavengers. We believe this paper can provide insight into the current PDA scavenging systems and offer inspiration towards the design of new melanin-inspired scavengers with a broad range of biomedical applications.
聚多巴胺（PDA）是最典型的一类合成黑色素，它具有诸如抗氧化、光保护、金属螯合和能量耗散等有趣的特性。在过去几年中，PDA已通过聚合方法成功合成，并展现出优异的自由基清除能力。其相关应用已迅速扩展至防晒霜、抗炎治疗和复合材料制造等领域。尽管取得了巨大进展，但其自由基清除行为的全面机制尚未完全明晰。本文致力于总结PDA自由基清除剂可能的机制、已确立的抗氧化调节方法及其相关生物医学应用。我们相信，本文能够为当前的PDA清除系统提供见解，并为设计具有广泛生物医学应用的新型黑色素启发式清除剂提供灵感。
