Department of Psychiatry, Inha University Hospital, Incheon, South Korea.
Department of Psychiatry, Kyungpook National University Hospital, Daegu, South Korea.
Psychogeriatrics. 2020 Nov;20(6):850-857. doi: 10.1111/psyg.12592. Epub 2020 Aug 17.
The aim of this study was to investigate the association between subjective memory complaint (SMC) and executive function in a community sample of South Korean elderly.
Data for 1442 non-cognitive impaired elderly individuals aged 65 and over were selected from a nationwide dementia epidemiological study conducted in South Korea. Global cognitive function was assessed by the Korean version of the Mini-Mental State Examination (MMSE-KC). The registration and recall subscales of the MMSE were used for evaluating memory function. Executive function was measured by using the Initiation/Perseveration (IP) subscale of the Korean dementia rating scale (K-DRS).
Of the 1442 participants, 1088 were in the normal control group and 354 were in the SMC group. In the SMC group, compared to the normal control group, the proportion of depression was significantly higher, total MMSE scores, delayed recall score and total IP scores were significantly lower, and the mean scores of complex/simple verbal IP, alternating movements, and graphomotor design were lower. In the unadjusted linear regression model, the SMC significantly associated with a lower score of total MMSE-KC, MMSE delayed recall, K-DRS IP, complex/simple verbal IP, alternating movements and graphomotor design. After adjusting for age, gender, education, marital status, alcohol consumption, smoking behaviour, and depression, the SMC were significantly associated with lower total MMSE score, MMSE delayed recall, K-DRS IP, and K-DRS complex/simple verbal IP.
In this population-based sample, individuals with SMC had evidence of lower performance on global cognition, memory function, and executive function, especially verbal fluency, after adjusting for demographic variables and depression.
本研究旨在调查韩国老年人群体中主观记忆主诉（SMC）与执行功能之间的关系。
从韩国进行的全国性痴呆流行病学研究中选择了 1442 名年龄在 65 岁及以上、无认知障碍的老年人的数据。采用韩国版简易精神状态检查（MMSE-KC）评估总体认知功能。使用 MMSE 的登记和回忆分量表评估记忆功能。使用韩国痴呆评定量表（K-DRS）的启动/坚持（IP）分量表评估执行功能。
在 1442 名参与者中，1088 名属于正常对照组，354 名属于 SMC 组。在 SMC 组中，与正常对照组相比，抑郁比例显著更高，总 MMSE 评分、延迟回忆评分和总 IP 评分显著更低，复杂/简单言语 IP、交替运动和图形运动设计的平均评分也更低。在未调整的线性回归模型中，SMC 与总 MMSE-KC、MMSE 延迟回忆、K-DRS IP、复杂/简单言语 IP、交替运动和图形运动设计评分较低显著相关。在调整年龄、性别、教育程度、婚姻状况、饮酒、吸烟行为和抑郁后，SMC 与总 MMSE 评分、MMSE 延迟回忆、K-DRS IP 和 K-DRS 复杂/简单言语 IP 评分较低显著相关。
在本基于人群的样本中，调整人口统计学变量和抑郁后，SMC 与整体认知、记忆功能和执行功能（特别是言语流畅性）下降有关。
