韩国晋州 20 年来母婴至老年人群感染血清流行率变化。
Changes in Seroprevalence of Infection over 20 Years in Jinju, Korea, from Newborns to the Elderly.
机构信息
Department of Pediatrics, Gyeongsang National University College of Medicine and Gyeongsang National University Hospital, Jinju, Korea.
Institute of Health Sciences, Gyeongsang National University, Jinju, Korea.
出版信息
J Korean Med Sci. 2020 Aug 17;35(32):e259. doi: 10.3346/jkms.2020.35.e259.
BACKGROUND
The objective of this study was to examine changes in the prevalence of cytotoxic-associated gene A (CagA) positive infection in Jinju, Korea, over the last 20 years.
METHODS
Three cross-sectional analyses were conducted concurrently. A total of 1,305 serum samples were collected from 1994-1995, 2004-2005, and 2014-2015, respectively. The presence of immunoglobulin (Ig) G, IgA, and IgM antibodies against CagA protein was examined by western blotting.
RESULTS
Overall, seropositivity for anti-CagA IgG antibody was significantly decreased from 63.2% to 42.5% over the last 20 years ( < 0.001). Anti-CagA IgG seropositivities in children and young adults aged 10-29 years decreased from 1994 (60.0%-85.0%) to 2015 (12.5%-28.9%). The age when plateau of increasing IgG seropositivity was reached in each study period shifted from the 15-19 year-old group in 1994-1995 (85.0%) to the 40-49 year-old group in 2014-2015 (82.5%). Overall seropositive rates of anti-CagA IgA and IgM antibodies did not change significantly either over the last 20 years.
CONCLUSION
infection rate in children and young adults declined over 20 years in Jinju, probably due to improved sanitation, housing, or economy.
背景
本研究旨在检测过去 20 年韩国晋州地区细胞毒素相关基因 A（CagA）阳性感染的流行率变化。
方法
同期进行了 3 项横断面分析。分别于 1994-1995 年、2004-2005 年和 2014-2015 年采集了 1305 份血清样本。通过 Western blot 检测 IgG、IgA 和 IgM 抗体针对 CagA 蛋白的存在情况。
结果
总体而言，抗 CagA IgG 抗体的血清阳性率在过去 20 年中从 63.2%显著下降至 42.5%（<0.001）。10-29 岁儿童和青年的抗 CagA IgG 血清阳性率从 1994 年（60.0%-85.0%）下降至 2015 年（12.5%-28.9%）。每个研究期间 IgG 血清阳性率达到峰值的年龄从 1994-1995 年的 15-19 岁组（85.0%）转变为 2014-2015 年的 40-49 岁组（82.5%）。过去 20 年，抗 CagA IgA 和 IgM 抗体的血清总阳性率也没有明显变化。
结论
晋州地区儿童和青年的感染率在过去 20 年中下降，这可能归因于卫生、住房或经济条件的改善。
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