Department of Human Molecular Genetics, Federal Research Center 'Institute of Cytology and Genetics', the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia Federation.
Laboratory of Endocrinology, N. Laverov Federal Center for Integrated Arctic Research, Arkhangelsk, Russia Federation.
Am J Mens Health. 2020 Jul-Aug;14(4):1557988320939714. doi: 10.1177/1557988320939714.
Male populations in the European North of Russia have not previously been investigated for semen quality. The aim of this study was to evaluate semen parameters, reproductive hormone levels, and lipid levels in volunteers from the general urban population of the European North of Russia, to compare the data published for men from the neighboring Northern or Eastern European countries, and to evaluate associations between sperm quality and serum hormonal and lipid levels. Ninety-nine volunteers aged 23-63 years residing in the city of Archangelsk were enrolled in the study. All men had blood samples drawn and completed a questionnaire concerning their health status and lifestyle; 90 men delivered semen samples. The medians for semen volume, sperm concentration, progressive motility, and normal morphology were 3.0 ml, 42.12 million/ml, 43.8%, and 6.5%, respectively. Sperm parameters below normal threshold values were found in 38.9% of participants. It seems that the sperm quality in our study group was slightly worse than in men from Finland, Norway, Sweden, or Estonia, but very similar to that in men from Denmark or Poland. The significant negative correlations of luteinizing hormone levels and positive correlations of inhibin B levels with sperm concentration and progressive motility were revealed. Higher levels of luteinizing hormone and lower levels of inhibin B were found in participants with impaired compared to normal sperm quality. No reliable links were found between serum total cholesterol, triglyceride, high and low-density lipoprotein cholesterol, and semen parameters.
俄罗斯北部欧洲地区的男性人口此前并未进行过精液质量研究。本研究旨在评估俄罗斯北部欧洲地区普通城市人口志愿者的精液参数、生殖激素水平和血脂水平，比较与来自北欧或东欧邻国的男性数据，并评估精子质量与血清激素和血脂水平之间的关系。99 名年龄在 23-63 岁的志愿者居住在阿尔汉格尔斯克市，参与了这项研究。所有男性都抽取了血液样本并填写了一份关于他们健康状况和生活方式的问卷；90 名男性提供了精液样本。精液量、精子浓度、前向运动精子比例和正常形态精子比例的中位数分别为 3.0ml、42.12 百万/ml、43.8%和 6.5%。有 38.9%的参与者的精子参数低于正常阈值。研究组的精子质量似乎略逊于芬兰、挪威、瑞典或爱沙尼亚的男性，但与丹麦或波兰的男性非常相似。研究发现，黄体生成素水平与精子浓度和前向运动精子比例呈显著负相关，而抑制素 B 水平与精子浓度和前向运动精子比例呈显著正相关。与正常精子质量相比，精子质量受损的参与者的黄体生成素水平较高，抑制素 B 水平较低。未发现血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇与精液参数之间存在可靠的联系。
