果蝇胚胎发育过程中空间模式化的engrailed基因表达的两层调控。
Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis.
作者信息
DiNardo S, Sher E, Heemskerk-Jongens J, Kassis J A, O'Farrell P H
机构信息
Department of Biochemistry and Biophysics, UCSF School of Medicine 94143-0448.
出版信息
Nature. 1988 Apr 14;332(6165):604-9. doi: 10.1038/332604a0.
Abstract
A regulatory cascade, initiated during the syncytial stage of embryogenesis, culminates in the striped pattern of engrailed gene expression at the cellular blastoderm stage. The early regulatory genes, for example the pair-rule genes, are expressed transiently and as their products decay a distinct regulatory programme involving segment polarity genes takes over. This late programme maintains and perhaps modifies the striped pattern of engrailed expression through interactions that may involve cell communication.
摘要
在胚胎发育的合胞体阶段启动的一个调控级联反应，在细胞胚盘阶段以条纹状的engrailed基因表达模式达到顶峰。早期调控基因，例如成对规则基因，短暂表达，随着它们的产物降解，一个涉及体节极性基因的不同调控程序接管。这个晚期程序通过可能涉及细胞通讯的相互作用维持并可能修饰engrailed表达的条纹模式。
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