Yim Gyeonghye, Kang Seounghun, Kim Subean, Jang Hongje
Department of Chemistry, Kwangwoon University, 20 Gwangwoon-ro, Nowon-gu, Seoul 01897, Republic of Korea.
Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea.
Nanomaterials (Basel). 2023 May 23;13(11):1706. doi: 10.3390/nano13111706.
Owing to multiple physicochemical properties, the combination of hybrid elemental compositions of nanoparticles can be widely utilized for a variety of applications. To combine pristine tellurium nanorods, which act as a sacrificing template, with another element, iridium-tellurium nanorods (IrTeNRs) were synthesized via the galvanic replacement technique. Owing to the coexistence of iridium and tellurium, IrTeNRs exhibited unique properties, such as peroxidase-like activity and photoconversion. Additionally, the IrTeNRs demonstrated exceptional colloidal stability in complete media. Based on these properties, the IrTeNRs were applied to in vitro and in vivo cancer therapy, allowing for the possibility of multiple therapeutic methodologies. The enzymatic therapy was enabled by the peroxidase-like activity that generated reactive oxygen species, and the photoconversion under 473, 660 and 808 nm laser irradiation induced cancer cell apoptosis via photothermal and photodynamic therapy.
由于具有多种物理化学性质，纳米颗粒混合元素组成的组合可广泛应用于各种领域。为了将作为牺牲模板的原始碲纳米棒与另一种元素结合，通过电化置换技术合成了铱-碲纳米棒（IrTeNRs）。由于铱和碲的共存，IrTeNRs表现出独特的性质，如类过氧化物酶活性和光转换。此外，IrTeNRs在完全培养基中表现出优异的胶体稳定性。基于这些性质，IrTeNRs被应用于体外和体内癌症治疗，实现了多种治疗方法的可能性。类过氧化物酶活性产生活性氧实现酶促治疗，473、660和808nm激光照射下的光转换通过光热和光动力疗法诱导癌细胞凋亡。
